How Does Lipo 6 Work
Let's take a close look at some of the key ingredients.
Coleus Forskohili in Lipo 6 - this is a herb that's been used in Indian medicine
for centuries. It's mainly used to relax the airways
in your lungs to help breathing. It also elevates
cAMP (cyclic adenosine monophosphate) levels, which
regulate active enzymes required for cellular energy
transfer. It also helps lower blood pressure.
Although unable to find studies of Coleus Forskohili on human subjects, I was able to find several studies done on rats which showed promise for weight loss effects. Below is one of the studies:
The Study: The anti obesity effects of Coleus forskohlii were investigated in ovariectomized (ovx) rats. Eight-week-old female Wistar rats were assigned to four groups: a sham-operated group fed the control diet (MF, sham-m) ; an ovx-m group fed the control diet; a sham-operated group fed the control diet containing 50 g/kg of Coleus forskohlii extract (sham-c) ; and an ovx-c group fed the control diet containing 50 g/kg of Coleus forskohlii extract. The body weight, adipose tissues, and cell diameter were investigated in ovx rats after Coleus forskohlii extract treatment. Administration of Coleus forskohlii extracts reduced body weight, food intake, and fat accumulation in ovx rats. Our results suggest that Coleus forskohlii may be useful in the treatment of obesity.
Han LK, Morimoto C, Yu RH, Okuda H.
Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Kumamoto 862-8502, USA. hanlikun@hotmail.com
In short, taking Coleus forskohili extract lead to reduced body weight, lower food intake, and also reduced fat accumulation.
Citrus aurantium in Lipo 6 - also known as bitter orange, Citrus aurantium has been used
in Chinese medicine to treat chest congestion. Citrus
aurantium has a rare combination of 5 amines: synephrine,
N-methyltyramine, hordenine, octopamine, and tyramine,
which "stimulates beta-3 cell receptors"
that could lead to increase in your metabolic rate
without affecting heart rate or blood pressure.
The added benefit of
Citrus aurantium is this ability to stimulate beta-3
cell receptors, which helps breakdown fat, increase
energy, and increase metabolic rate, hence making
thermogenesis more effective. Studies show that Citrus
aurantium may also act to suppress appetite. I should point out
that the biggest benefit of Citrus aurantium is that
several compound found in Citrus aurantium are structurally
similar to ephedrine and act as stimulants, but these
do not appear to have the same negative side effects
of ephedrine.
There are several studies done on Citrus aurantium, and I had no problems finding quite a few studies done on this ingredient that demonstrated positive weight loss effects on human subjects. Below is a study conducted by the department of physiology, medicine and pathology at the Georgetown university.
The Study: Obesity is a serious health problem throughout the world. More than half of U.S. adults are overweight (61%) and more than a quarter (26%) of U.S. adults are obese. The inability of many individuals to keep their weight in check by diet and exercise has created a need for additional therapeutic means to combat obesity. Despite great effort, the pharmaceutical industry has not come up with the solution; because most weight-loss drugs to date have serious adverse effects to health and well-being.
The theory that beta agonists, especially beta 3 agonists, can affect body weight and fat mass is well accepted. Ephedrine has proven time and time again that it is an effective weight loss agent through its ability to increase thermogenesis and quench appetite. However, the publicity concerning adverse reactions has led to its gradual withdrawal from use by many despite the perceived consequences of obesity. Many companies are now substituting Citrus aurantium for ephedra in their formulations.
Citrus aurantium, an agent containing beta agonists, has been reported to aid in weight loss in two studies and increase thermogenesis, at least to some extent, in three studies. Colker et al. (1999) reported that in a double-blind, placebo-controlled, randomized study the sof Citrus aurantium, caffeine and St John's Wort, lost significant amounts of total body weight while on a strict diet and exercise. Those in the placebo and control groups who also were on the same restricted diet did not. However, intergroup analysis showed no statistical significance among the weight changes in the three groups. In contrast, the loss of fat mass in the test group was significantly greater compared to the placebo and control groups.
Jones describes an open labeled study performed on 9 women. The subjects showed a mean of 0.94 kg lost during the first week when no product was given and 2.40 kg during the second week when a Citrus aurantium product was taken. Body weight losses were statistically greater during the second week compared to the first week. Since most clinicians would agree that the most weight loss should occur initially coinciding with a greater fluid loss during the first week, these differences are even more remarkable. Three studies reported increased metabolic rates when ingesting Citrus aurantium products, however, at least two of these studies were acute. At present, Citrus aurantium may be the best thermogenic substitute for ephedra. However, more studies are needed to establish this definitively.
Preuss HG, DiFerdinando D, Bagchi M, Bagchi D.
Department of Physiology, Medicine and Pathology, Georgetown University Medical Center, Washington, DC 20057, USA. preusshg@georgetown.edu
The basis of the above study is peer reviews of other studies done on Citrus aurantium, several of which demonstrated promising weight loss benefits. I found no shortage of such types of "studies" and peer reviews, which all write positively for the promising effects of Citrus aurantium; however, most of these studies are also calling for more studies to determine the efficacy of Citrus aurantium.
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Lipo 6 Carnitrex™ also known as L-Carnitine L-Tartrate is claimed by Nutrex to "transport fatty acids through bloodstream into muscles where they can be burnt as energy." While this sounds great, I was unable to find any studies to substantiate these claims. However, I did come across numerous studies done on L-Carnitine L-Tartrate, which demonstrated the positive effects this ingredient has on recovery after exercising. Below are brief summaries of two such studies.
Study 1: The purpose of this investigation was to examine the influence of L-carnitine L-tartrate (LCLT) supplementation using a balanced, cross-over, placebo-controlled research design on the anabolic hormone response (i.e., testosterone [T], insulin-like growth factor-I, insulin-like growth factor-binding protein-3 [IGFBP-3], and immunofunctional and immunoreactive growth hormone [GHif and GHir]) to acute resistance exercise.
Ten healthy, recreationally weight-trained men (age 23.7years, weight 78.7kg, and height 179.2 cm) volunteered and were matched, and after 3 weeks of supplementation (2 g LCLT per day), fasting morning blood samples were obtained on six consecutive days (D1-D6). Subjects performed a squat exercise (5 sets of 15-20 repetitions) on D2. During the squat protocol, blood samples were obtained before exercise and 0, 15, 30, 120, and 180 minutes postexercise. After a 1-week washout period, subjects consumed the other supplement for a 3-week period, and the same experimental protocol was repeated using the exact same procedures.
Over the recovery period, LCLT reduced the amount of exercise-induced muscle tissue damage, which was assessed via magnetic resonance imaging scans of the thigh. LCLT supplementation significantly (p < 0.05) increased IGFBP-3 concentrations prior to and at 30, 120, and 180 minutes after acute exercise.
These data support the use of LCLT as a recovery supplement for hypoxic exercise and lend further insights into the hormonal mechanisms that may help to mediate quicker recovery.
Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gomez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Hakkinen K.
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. kraemer@uconnvm.uconn.edu
Study 2 Twelve healthy active subjects (6 male, 6 female) performed 60 min of exercise (60% VO(2max)) on 3 occasions after supplementing with L-Carnitine L-tartrate (LCLT) or placebo. Each subject received a chronic dose, an acute dose, and placebo in a randomized, double-blind crossover design. Dietary intake and exercise were replicated for 2 d prior to each trial.
No effects on fat oxidation or hematological responses were noted in either gender group. Under these experimental conditions, chronic LCLT supplementation increased CHO oxidation in males during exercise but this was not observed in females.
Abramowicz WN, Galloway SD.
Dept of Sports Studies, University of Stirling, Stirling, Scotland.
In a nutshell, these studies found that while L-Carnitine L-Tartrate, or Carnitrex as Lipo 6 likes to call it, did not produce any fat oxidation results; however, supplementing Carnitrex is beneficial for post exercise recovery.
Yohimbine HCL is another key ingredient in Nutrex Lipo 6 diet pill. It is an alkaloid found in the inner bar of a tree grown in south Africa. Yohimbe has been used as an aphrodisiac for centuries, and is now showing some promise in the areas concerning weight loss. Although there are still relatively few studies done on Yohimbe's effects on fat loss, I managed to find several of them. Below is a very promising study demonstrating the positive effects Yohimbine has on body fat composition.
Study: The main aim of this study was to determine the effects of yohimbine supplementation on body composition and exercise performance in professional soccer players. The athletes (20 top-level male soccer players) were allocated to two randomly assigned trials.
Subjects in the yohimbine group orally ingested tablets that contains yohimbine at a dose of 20 milligrams per day in two equal doses for 21 days. Subjects in the placebo group ingested an equal number of identical-looking pills that contained cellulose.
There were no statistically significant changes in body mass and muscle mass within or between trials (p > 0.05) after the supplementation protocol. Percentage of body fat significantly decreased in the yohimbine group after the supplementation protocol (9.3 +/- 1.1 vs. 7.1 +/- 2.2%; p < 0.05).
Furthermore, fat mass was significantly lower in the yohimbine versus placebo trial at post supplementation assessment (7.1 +/- 2.2 vs. 9.2 +/- 1.9%; p < 0.05). There were no changes in exercise performance indicators (bench and leg press, vertical jump, dribble and power test results, shuttle run) within or between. trials (p > 0.05).
No subject reported any side effects from yohimbine. The results of the current study indicate that supplementation with yohimbine combined with resistance training does not significantly alter the body mass, muscle mass, or performance indicators in professional soccer players. Nonetheless, yohimbine supplementation appears to be suitable as a fat loss strategy in elite athletes.
Ostojic SM. Institute of Sports Medicine, Sports Academy, Belgrade, Serbia and Montenegro. sergej@panet.co.yu
To sum up the above findings, the researchers found that while Yohimbine had no effects of exercise performance or body mass changes, it helped reduce the body fat mass in subjects that took the Yohimbine supplement, leading to the conclusion that taking Yohimbine supplement is an effective way to lose body fat.
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Nutrex Lipo 6 Fat Burner Review
I certainly hope that I haven't bored you with all the study highlights of the key active ingredients in the Lipo 6 diet pill; however, I think its important to understand how the active ingredients work, and to find specific scientific studies to backup (or refute) the claims made by the manufacturers. With the hundreds (if not thousands) of diet pill products on the market today, and the lackluster regulatory enforcement, it's important to do some digging of your own to truly find out if a particular diet pill is all marketing hype with no real substance, or if it's worth its weight in gold.
In the above review of Nutrex Lipo 6 diet pill, we've laid out some key scientific studies that speaks well of the ingredients used in Lipo 6 pertaining to fat loss and body fat composition; however, if it were a perfect world, everything in life would workout exactly the way we plan it. Unfortunately, it is not so, and like everything else, because the uniqueness of each individual, and each situation involved, what seems like the perfect solution in studies may turn out to be a real disappointment.
While considering all the factors of Lipo 6, we cannot base our review of this diet pill solely on the basis of scientific studies, but also, we rely on the numerous feedbacks, reviews, and testimonials from actual users - users like yourself.
The Nutrex Lipo 6 diet pill received an average user rating of 3.7 out of 5. While most users had positive experiences with Lipo 6, there are users who did not speak well of Lipo 6, and this will always be the case for any type of product. Each individual is uniquely different, and will experience different effects of Lipo 6. Some individuals will have great fat loss success with almost no side effects, and other individuals will experience little to no weight loss with many side effects. It's never a for sure thing, and you just won't know until you've tried it yourself to know how you react to it. You can read all the Lipo 6 user testimonials here.
Nutrex Lipo 6 Side Effects
As with all fat burners and diet pills, Nutrex Lipo 6 also has its side effects. Some side effects of Lipo 6 include:
- Increase in energy levels
- Anxiety, shaking, and light headedness
- Cramps, numbness, light headaches, feeling
faint
- Increased heart rate and a rapid heart beat
- Increased sweating
- Nausea and upset stomachs
- can disrupt sleep patterns, especially if
taken late at night (which is why it clearly states on the label to not take Lipo 6 within 6hours of going to sleep.)
Like all fat burners, do not start off with the full recommended dose. Instead, take only half dose for the first few days, get a feel for the diet pill, see how your body reacts to it, and if all goes will, then you can follow the suggested dosage.
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