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Health & Supplements

5 Steps To Back Pain Relief
Acai Berry Juice Review
Acai Berry Studies
Acetyl L-Carnitine Information
Aloe Vera Juice, Gel & Health
Alpha Lipoic Acid Info
Amino Acid Supplment
Arginmax for Men Review
Arginmax for Women Review
Artichoke Leaf Extract
Ashwagandha Extract
Astragalus Root Herb
Back Pain Treatment
Back Pain Relief - Lower Back Pain
Black Cohosh Side Effects
Black Cohosh Benefit & SIde Effects
Blood Tests - Understanding 1
Blood Test - Understanding 2
Borage Oil GLA Benefits
Bromelain Quercetin Benefits
Calcium Supplement Benefit
Calcium Deficiency
Cause of Lower Back Pain
CoEnzyme Q10 - CoQ10 Info
Coral Calcium Supplement
Damiana Leaf & Herb Extract
Degenerative Disc Disease
Echinacea Golden Seal
Flax Seed Oil Health Benefits
Ginkgo Biloba Information
Ginseng Root Benefit
Glucosamine Chondroitin
Grape Seed Extract Benefits
Green Tea Extract Benefits
Guggul Extract - Guggulsterone
Herbalife Prelox Blue Review
Herniated Disc Treatment
Herniated Disc & Back Pain
Joint Pain & Joint Health - 1
Joint Pain & Joint Health - 2
Lactobacillus Acidophilus
Lifezyme Plus - Pain Relief
L-Arginine Benefit & Side Effects
L-Lysine Cold Sore & Benefits
L-Taurine Benefit & Side Effects
L-Tryptophan 5 HTP & Depression
Monavie Acai Juice Drink Review
Milk Thistle Benefit & Side Effects
Mineral Supplements and Health
Omega 3 Fish Oil Supplement
Piriformis Syndrome - Sciatic Pain
Pycnogenol Benefits & Side Effects
Saw Palmetto Herb Extract
Soy Protein Powder Benefits -1
Soy Protein Powder Benefits -2
Zrii Amalaki Drink Review

Vitamin Guides & Articles

Vitamin for Acne Treatment
Vitamin A & Beta Carotene
Vitamin A Deficiency & Carotene
Vitamin B Complex Benefit
Vitamin B1 Thimaine
Vitamin B1 Thiamine Deficiency
Vitamin B2 Riboflavin
Vitamin B2 Riboflavin Deficiency
Vitamin B3 Niacin
Vitamin B3 Niacin Deficiency
Vitamin B5 Pantothenic Acid & Acne
Vitamin B5 Pantothenic Acid Benefit
Vitamin B6 Pyridoxine
Vitamin B6 Pyridoxine Health Benefit
Vitamin B7 Biotin & Hair Loss
Vitamin B7 Biotin Deficiency
Vitamin B9 Folic Acid Pregnancy
Vitamin B9 Folic Acid Deficiency
Vitamin B12 Benefit & Side Effects
Vitamin B12 Deficiency & Symptoms
Vitamin C Ascorbic Acid
Vitamin C Health Benefits
Vitamin C Deficiency Symptoms
Vitamin C and Vitamine E
Vitamin D Benefits
VItamin D Deficiency Symptoms
Vitamin E Health Benefit
Vitamin E Deficiency Symptoms
Vitamin K Food & Benefit
Vitamin K Deficiency Symptoms
Vitamin K Supplements

Vitamin B12 Cobalamin Benefit & Side Effects

Health Benefit of Vitamin B 12 Cobalamin

Vitamin B12 is the largest and most complex of all the vitamins. It is unique among vitamins in that it contains a metal ion, cobalt. For this reason cobalamin is the term used to refer to compounds having B-12 activity. Methylcobalamin and 5-deoxyadenosyl cobalamin are the forms of vitamin B-12 used in the human body. The form of cobalamin used in most supplements, cyanocobalamin, is readily converted to 5-deoxyadenosyl and methylcobalamin.

Cobalamin is known to keep your red blood cells healthy. If you eat enough cobalamin, and if your body can use it properly, you make millions of nice round, healthy red blood cells every day. If you don't eat enough, or you can't use it properly, you can't make enough red blood cells, and the ones you do make are too large and fragile to work well. When you don't have enough red blood cells to carry oxygen and nutrients around your body, you develop anemia.

All your cells, not just your red blood cells, need cobalamin to grow and divide properly. For example, you need it to make all the different cells in your immune system, including white blood cells.

Cobalamin's next big role is in making the protective fatty layer, or sheath, that coats your nerve cells - sort of like insulation on electric wires. If the sheath is damaged because you don't have enough vitamin b12 cobalamin, you start getting the equivalent of static on the line. Really bad static can interfere with your mental function - so much that people think you're senile.

Cobalamin is a team player. Working with the other B vitamins, but especially with pyridoxine and folic acid, it helps you turn the carbs, fats, and proteins in your food into energy in your cells.

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Vitamin B12 Side Effects

Generally, vitamin B12 side effects are quite rare; however there are reported cases of allergic reactions to vitamin b12 injections, but it is unknown if these allergic reactions are due to the vitamin b12 itself or the preservatives in the injectable vitamin b12. (Most vitamin b12 injections contain some preservatives).

Side Effects of Vitamin B12 can include:

  • Mild diarrhea
  • Anxieties and panic attacks
  • Heart palpitations
  • Insomnia
  • Breathing problems
  • Chest pain
  • Skin rash, hives, or itchy or swollen skin

Vitamin B 12 Benefit

Cobalamin and Cancer - Folate is required for synthesis of DNA and there is evidence that decreased availability of folate results in strands of DNA that are more susceptible to damage. Deficiency of vitamin B 12 traps folate in a form that is unusable by the body for DNA synthesis. Both vitamin B 12 and folate deficiencies result in a diminished capacity for methylation reactions.

Thus, vitamin B 12 deficiency may lead to an elevated rate of DNA damage and altered methylation of DNA, both of which are important risk factors for cancer. A recent series of studies in young adults and older men indicated that increased levels of homocysteine and decreased levels of vitamin B 12 in the blood were associated with a biomarker of chromosome breakage in white blood cells. In a double-blind placebo- controlled study the same biomarker of choromosome breakage was minimized in young adults who were supplemented with 700 mcg of folic acid and 7 mcg of vitamin B-12 daily in cereal for two months.

Vitamin B 12 Cobalamin and Depression - Observational studies have found as many as 30% of patients hospitalized for depression to be deficient in vitamin B-12. A recent cross-sectional study of 700 community-living physically disabled women over the age of 65 found that vitamin B-12 deficient individuals were twice as likely to be severely depressed as non-deficient individuals. The reasons for the relationship between vitamin B 12 deficiency and depression are not clear.

Vitamin B 12 and folate are required for the synthesis of S-adenosylmethionine, a methyl group donor essential for the metabolism of neurotransmitters, whose bio availability has been related to depression. Because few studies have examined the relationship of vitamin B-12 status and the development of depression over time, it cannot yet be determined if vitamin B 12 deficiency plays a causal role in depression. However, due to the high prevalence of vitamin B-12 deficiency in older individuals, it may be beneficial to screen them for vitamin B 12 deficiency as part of a medical evaluation for depression.


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