Igf-1

[tbone]

hey bros been doing a lot of reading on IGF-1 i was wondering what you guys think of the stuff

[ryanbodybuilder]

its definately something i want to try out soon too.....its really expensive and the effects wear off after 4 weeks...so 4 weeks is ussually the longest you want to run it..and ussually to be safe only 3 times a year

[Poobah]

Some people swear by it.. others don't see much results..

The reviews that i really like are by the guys with -8% body fat that swear by it..

Generally reviews are mixed at doses of 40mcg per day... 50% positive and 50% inconclusive.

i've ran it at 50mcg a day, during pct, and noticed it probably helped my mood, and it definately helped my nuts come back quicker.. but nothing really noticeble mucsle wise.

I have also ran it mid cycle with slin, and I definately noticed my whole body was pumped, and cramped to high hell.. and i got muscle cramps and twitches in the strangest of places.. It was obvious it had a very synrgistic effect with slin and aas... I was growing uncontrollably it seemed.

I've recently ran it at 100mcg for 20 days... which just so happens to coincide with the time I moved my bench press from 10 x 225 to 10 x 260... or a max of 340. Was it coincidence? I think partly it was, but partly I had recovery out the ying yang, and I believe 100mcg is the effective stand alone dose.. but for best results aas should be right along side it.

Generally reviews seem to show people that are taking in excessess of 100mcg a day more often then not enjoy the effects.. and make noticable gains.

Again, though I'd highly recommend it in addition to a aas cycle... one will feed the other and vice versa.

I'd actually like to see someone run SD for 3 weeks along side of 100mcg+ igf per day with a high carb diet... I bet it's an awsome combination.

[ryanbodybuilder]

yeah i agree superdrol+igf1+high carb diet=amazing cycle!!!!!!!!!
probably 20lbs gained in 3 weeks too!

[mywetnightmares]

Plus the hyperplasia would make gains easier to keep.

[tbone]

thanks bro i was gonna run it during pct.. I was wondering if you guys new any research companies that have it.. i understand its not illegal yet

[ryanbodybuilder]

muscle-research dot com?

[workoutbug]

Please be careful and do your research guys. IGF-1 is a intercellular growth factor and humans (healthy) already produce 10 mg per day.

Yes, there is research to show that IGF-1 (Insulin-like growth factor - 1) has anabolic properties, but it has also been show to stimulate any competent cells towards cell division and has therefore been linked to many types of cancer.

I just ask that you read up before you start altering your cell signalling, afterall, that's what cancer is really all about. If you have any questions please feel free to PM me.

[TRAZ]

/\ A very valid point! If I am understanding this correctly you could increase your chance of Cancer signifigantly by using. Ex:If you only have a few abnormal cells that wouldn't normally be dividing and then you add the Igf you would be multiplying your risks. Or if you had an undetected tumor you could be causing it to grow even larger...Am I correct?

[workoutbug]

Absolutely!

[TRAZ]

Scary stuff!

[Traps]

Originally Posted by TRAZ

Scary stuff!

Bump on that.....Not worth it in the least little bit. Better off just doing synthol.

[mywetnightmares]

I wouldn't worry about the cancer risk, from what I've read IGF-1 will simply make your cancer grow faster, but it won't give you cancer. If you already have it then you would have to deal with it anyway so you might as well deal with it sooner rather than later. If you don't have cancer then I don't see what reason there is to worry.

[workoutbug]

Originally Posted by mywetnightmares

I wouldn't worry about the cancer risk, from what I've read IGF-1 will simply make your cancer grow faster, but it won't give you cancer. If you already have it then you would have to deal with it anyway so you might as well deal with it sooner rather than later. If you don't have cancer then I don't see what reason there is to worry.

Please understand that that not all cells in your body that are damaged (in a way that would make them cancerous) would begin to divide (or grow). Your body had signalling pathways that can block damaged cells from becoming cancer or tumors, BUT using a cellular growth factor such as IGF-1 can signal that cell that would have stayed dormant or undergone apoptosis (cell death) to begin dividing (multiplying) and to become a tumor.

Please do a little reading from some scientific literature before you make these unscientific claims that can put people at risk.

[Poobah]

Originally Posted by workoutbug

Please be careful and do your research guys. IGF-1 is a intercellular growth factor and humans (healthy) already produce 10 mg per day.

Yes, there is research to show that IGF-1 (Insulin-like growth factor - 1) has anabolic properties, but it has also been show to stimulate any competent cells towards cell division and has therefore been linked to many types of cancer.

I just ask that you read up before you start altering your cell signalling, afterall, that's what cancer is really all about. If you have any questions please feel free to PM me.

you don't have your facts perfect... 10mg is not produced every day.. if your were to inject 10mg, or 10000mcg.. your blood sugar would drop and you'd probably die.

yes if you have cancer it would certainly speed it's growth, and yes since it does cause cell division it is possible that it could cause an onset of cancer... but then again, humans do produce hgh everyday, hgh does breakdown into growth factors, of which igf1 is the predominent, and every one always runs the risk of developing cancer.. so does eating red apples... and standing out in the sun to long.

All I'm saying is know the risks.. but don't automatically believe the worst... hgh is currently perscribed all around the world.. and igf is currently being tested and eventually will be prescribed to treat different problems as well.

If your completely concerned about your health.. body building is probably something you should consider stopping... its well known that people on calorie restricted diets tend to live the longest... big muscles does not support a healthy long lived life.

[workoutbug]

Take it easy there. I realize that many parts of body building are not perfectly healthy and that many people choose to use drugs or supplements that have the potential to harm. I only provided my information because someone was asking about this drug and they didn't seem to know a whole lot about it.

I am not saying don't use it, I am saying be careful and do your research and gather your facts first. It is important to go into things knowing what the risks are...in this case if you have any family history of cancer I think this is a foolish drug choice, but if anyone feels it's worth the risk go right ahead.

Your statment - "if your were to inject 10mg, or 10000mcg.. your blood sugar would drop and you'd probably die."

Is not right either. Here is a link to the drug fact and dosage sheet for IGF-1: http://www.factsandcomparisons.com/a..._rinfabate.pdf

In there you will see under Administration and Dosage that a maximum of 2mg/kg can be administered per day. This equals 2 mg/2.2 pounds. So, for a small person say 50kg or 110 lbs that would be 100mg per day.

Here is one of many articles that associate increased IGF-1 levels with not only the development of cancer, but also the increased aggressiveness of that cancer. Again, I am only providing information for an informed choice. I thought that's why we have forums like this. Insulting me isn't going to make the risks any different.


"1: Clin Cancer Res. 2005 May 1;11(9):3233-42. Related Articles, Links


Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases.

Furukawa M, Raffeld M, Mateo C, Sakamoto A, Moody TW, Ito T, Venzon DJ, Serrano J, Jensen RT.

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Hematopathology Section, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892-1804, USA.

PURPOSE: Growth factors, particularly insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) in some nonendocrine and a few endocrine tumors, are thought important in recurrence, growth, and aggressiveness. Whether this is true of neuroendocrine tumors such as gastrinomas is unclear. The aim of this study was to address this question in gastrinomas. EXPERIMENTAL DESIGN: IGF-I and IGF-IR expression in gastrinomas from 54 patients with Zollinger-Ellison syndrome were analyzed and correlated with clinical/tumor characteristics. IGF-I and IGF-IR mRNA levels were determined by competitive reverse transcription-PCR. IGF-IR expression, assessed by immunohistochemistry, was done on a subset. RESULTS: IGF-IR mRNA was found in 100% and IGF-I in 89%. IGF-I mRNA expression varied by >254-fold, IGF-IR by 2,670-fold, and the levels correlated in a given tumor. The IGF-IR level was lower in gastrinomas of patients who were rendered disease free and increased levels correlated with tumor growth, aggressiveness, extent, and with liver metastases. Increased IGF-I levels correlated with increased growth, tumor extent, and aggressiveness. Neither IGF-IR nor IGF-I levels correlated with tumor location, size, or its clinical/functional features. The IGF-IR correlated with disease-free survival. IGF-IRbeta was found in 31 of 32 tumors (97%) by immunohistochemistry. CONCLUSIONS: These results indicate that IGF-I and IGF-IR are expressed in almost all gastrinomas. Furthermore, assessment of IGF-I/IGF-IR expression in gastrinomas may be clinically useful in identifying those patients with more aggressive tumors who might benefit from more aggressive treatment.

PMID: 15867218 [PubMed - indexed for MEDLINE]

[Poobah]

alright... perhaps techinically your right..

but igf-1 isn't what is sold... igf-1 itself has a half life of almost zip and is needed in large doses or many doses over the course of a day to have much of an effect... igf1 was largely underground only used by the insane and rich.. cause frankly it is completely impracticle and cost prohibitive.

what is available now to anyone that wants it is.. R3IGF-I , which with a slight amino acid addition... now has half life of 12 hours or better... and 10000mcg would definately drop your blood sugar off the radar with in 45 minutes and definately probably kill you.

I'm not really argueing with you either.. I'm just trying to keep the pendulum in the middle somewhere.. what you say is correct.. there is risks, and if you do have a high rate of cancer in your family.. then you'd be best not to use this...

then again, some of the effects of igf, could actually increase the health of individual cells and repair damage caused by free radicals which could potencially lesson the risk of certain types of cancer.. but that's just me spinning my wheels a bit.. who knows.