Anabolic Steroid, HGH, IGF, Insulin and Ancillary Profiles

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All profiles taken with permission from Marky's board... Thanks bro!

Testosterone Enanthate

Testosterone enantate is an ester of the naturally occurring andro-gen, testosterone. It is responsible for the normal development of the male sex characteristics. In the event of insufficient testosterone production an almost complete balance of the functional, anatomic, and psychic deficiency symptoms can be achieved by substituting testosterone." (Excerpt from the package insert of the German phar-maceutical group, Jenapharm GmbH for its compound Testosteron--Depot.)

The decisive advantage of Testosterone enanthate, however, is that this substance has a very strong androgenic effect and is coupled with an intense anabolic component. This allows almost everyone, within a short time, to build up a lot of strength and mass. The, rapid and strong weight gain is combined with distinct water reten-tion since a retention of electrolytes and water occurs. A pleasant effect is that the enormous strength gain goes hand in hand with the water retention. Weightlifters and powerlifters, especially in the higher weight classes, appreciate this characteristic. In this group, Testosterone enanthate, Testosterone cypionate, and Sustanon (see also Sustanon) are the number one steroids; this is also clearly re-flected in the dosages. Dosages of 500 mg, 1000 mg or even 2000 mg per day are no rarity-mind you, per day, not per week. Sports disciplines requiring a high degree of raw power, aggressiveness, and stamina offer an excellent application for Depot-Testosterone. The distinct water retention has also other advantages. Those who have problems with their joints, shoul-der cartilages or whose intervertebral disks, due to years of heavy training, show the first signs of wear, can get temporary relief by taking testosterone.

For the bodybuilder, the water retention that goes hand in hand with Testosterone enanthate cuts both ways. Certainly, one gets rap-idly massive and strong; however, one's reflected image after a few weeks often shows completely flat, watery, and puffy muscles. The muscles appear as if they have been pumped up with air' to new dimensions, yet during flexing nothing happens. Those who do not believe this should bother to go visit the so-called "bodybuilding champions" during the OFF-season when these exaggerated quanti-ties of "Testo" come in. A look at the now defunct bodybuilding magazine WBF makes it even clearer. An additional problem when taking Testosterone enanthate is that the conversion rate to estrogen is very high. This, on one hand, leads the body to store more fat; on the other hand, feminization symptoms (gynecomastia) are not unusual. However, it must be clearly stated that this depends on the athlete's predisposition. By all means, there are athletes who even with 1000 mg +/week do not show feminization symptoms or fat deposits and who suffer very low water retention. Others, however, develop pain in their nipples by simply looking at a Testoviron-De-pot ampule. Yet the additional intake of Nolvadex and Proviron should be considered at a dosage level of 500 mg+ /week. As already men-tioned, Testo is effective for everyone, whether a beginner or Mr. Olympia.

Testosterone enanthate also strongly promotes the regen-eration process. This leads to distinctly shorter overcompensation phases, an increased feeling of well-being, and a distinct energy in-crease. This is also the reason why several athletes are able to work out twice daily for several hours six times a week and continue to build up mass and strength. Those who can work out again two hours after a hard leg workout know that Testo works. Athletes who take Testosterone enanthate report an excessively strong pump effect during training. This "steroid pump" is attributed to an in-creased blood volume with a higher oxygen supply and a higher quantity of red blood cells. Those who take megadoses of Testoster-one enanthate will already feel an enormous pump in their upper thighs and calves when climbing stairs. Despite this we recommend that steroid novices stay away from all testosterone compounds. To make it very clear: Those who have never taken steroids do not yet need any testosterone and should wait until later when the "weaker" steroids begin to have little effect. For the more advanced, Testoster-one enanthate can either be taken alone or in combination with other compounds.

For adding mass Testosterone enanthate combines very well with Anadrol 50, Dianabol, Deca-Durabolin, and Parabolan. As an ex-ample, a stack of 100 mg Anadrol 50/day, 200 mg Deca-Durabolin/ week, and 500 mg Testosterone enanthate/week works well. After six weeks of intake the Anadrol 50, for example, could be replaced by 40 mg Dianabol/day. Principally, Testosterone enanthate can be combined with any steroid in order to gain mass. Apparently a synergetic effect between the androgen, Testosterone enanthate, and the anabolic steroids occurs which results in their bonding witli sev-eral receptors.Those who draw too much water with Testosterone enanthate and Dianabol or Anadrol, or who are more intere6ted in strength without gaining 20 pounds of body weight should take Testosterone enanthate together with Oxandrolone or Winstrol. The generally taken dose-as already mentioned-varies from 250 mg/ week up to 2000 mg/day. In our opinion the most sensible dosage for most athletes is between 250-1000 mg/week. Normally a higher dosage should not be necessary When taking up to 500 mg/week the dosage is normally taken all at once, thus 2 ml of solution are injected. A higher dosage should be divided into two injections per week. The quantity of the dose should be determined by the athlete's developmental stage, his goals, and the quantity of his previous steroid intake. The so called beach- and disco bodybuilders do not need 1000 mg of Testosterone enanthate/week. Our experience is that the Testosterone enanthate dosage for many, above all, depends on their financial resources. Since it is not, by any means, the most economic testosterone, most athletes do not take too much. Others switch to the cheaper Omnadren and because of the low price con-finue "shooting" Omnadren.

Testosterone enanthate has a strong influence on the hypothalamohypophysial testicular axis. The hypophysis is inhib-ited by a positive feedback. This leads to a negative influence on the endogenic testosterone production. Possible effects are described by the German Jenapharm GmbH in their package insert for the com-pound Testosteron Depot: " In a high-dosed treatment with test-osterone compounds an often reversible interruption or reduction of the spermatogenesis in the testes is to be expected and conse-quently also a reduction of the testes size." Consequently, after reading these state-ments, additional intake of HCG should be considered. Those who take Testosterone enanthate should consider the intake of HCG ev-ery 6-8 weeks. An injection of 5000 I.U. every fifth day over a period of 10 days (a total of 3 injections) helps to reduce this problem. At the end of the testosterone treatment the administration of HCG, Clomid, Nolvadex and Clenbuterol is now quite common. To some extent the use of these compounds helps absorb the catabolic phase and helps elevate the endogenic testosterone level. By this method the strength and mass loss which occur in any event can be reduced. Those who go off Testosterone enanthate 6cold turkey6 after several weeks of use will wonder how rapidly their body weights and former voluminous muscles will decrease. Even a slow tapering-off phase, that is reducing the dosage step by step, will not prevent a notice-able reduction. The only options available to the athlete consist of taking testosterone-stimulating compounds (HCG, Clomid, Cyclofenil), anti-catabolic substances (Clenbuterol, Ephedrine), or the very expensive growth hormones, or of switching to milder steroids (Deca-Durabolin, Winstrol, Primobolan). Most can get mas-sive and strong with Testosterone enanthate. However, only very few are able to retain their size after discontinuing the compound. This is also one of the reasons why really good bodybuilders, powerlifters, weightlighters, and others take the "stuff " all year long.

The side effects of Testosterone enanthate are mostly the distinct androgenic effect and the increased water retention. This is usually the reason for the frequent occurrence of hypertony (3). Those who have a predisposition for high blood pressure or whose blood pres-sure is elevated when they begin taking Testosterone enanthate should have it periodically checked by a physician. If necessary the intake of an antihypertensive drug (4) such as Catapresan is advisable. Many athletes experience a strong acne vulgaris with Testosterone enanthate which manifests itself on the back, chest, shoulders, and arms more than on the face. Athletes who take large quantities of Testo can often be easily recognized because of these characteristics. It is interesting to note that in some athletes these characteristics only occur after use of the compound has been discontinued, which implies a rebound effect. In severe cases the medicine Accutane can help. The already discussed feminization symptoms, especially gynecomastia, require the intake of an anti-estrogen. Sexual overstimulation with frequent erections at the beginning of intake is normal. In young athletes, "in addition to virilization,testosterone can also lead to an accelerated growth and bone maturation, to a premature epiphysial closing of the growth plates and thus a lower height" (Jenapharm GmbH, package insert for Testosteron-Depot).' Since mostly taller athletes are successful in bodybuilding, young adults should reflect carefully before taking any anabolic/andro-genic steroids, in particular, testosterone.

Doses: 250 mg - 1000 mg a week
Side effects: Medium
Strength & Mass gains: Good and solid

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Testosterone Propionate

Testosterone propionate, after Testosterone cypionate and enanthate, is the third injectable testosterone ester that needs to be described in detail. This makes sense because, unlike cypionate and enanthate, both of which are widely used and well-spread in Europe, proprionate is little noticed by most athletes.

The reader will now certainly pose the question of why the characteristics of an apparently rarely used substance are described in detail. At a first glance this might seem a little unusual but when looking at this substance more closely, there are several reasons that become clear. Testosterone propionate is used on so few occasions in weightlifting, powerlifting, and bodybuild-ing not because it is ineffective. On the contrary, most do not know about propionate and its application potential. One acts according to the mottos "what you don't know won't hurt you" and "If oth-ers don't use, it can't be any good." We do not want to go this far and call propionate the most effective testosterone ester-, however, in certain applications it is superior to enanthate, cypionate, and also undecanoate because it has characteristics which the common test-osterones do not have.

The main difference between propionate, cypionate, and enanthate is the respective duration of effect. In contrast to the long-acting enanthate and cypionate depot steroids, propionate has a distinctly lower duration of effect. The reader learns how long this time is from the package insert of the German Jenapharm GmbH for their compound "Testosteron Jenapharm" (see list with trade 'names): "Testosterone proprionate has a duration of effect of I to 2 days." An eye-catching difference, however, is that the athlete "draws" distinctly less water with propionate and visibly lower water retention occurs. Since propionate is quickly effective, often after only one or two days, the athlete experiences an increase of his training energy, a better pump, an increased appe-tite, and a slight strength gain. As an initial dose most athletes pre-fer a 50-100 mg injection. This offers two options: First, because of the rapid initial effect of the propionate-ester one can initiate a sev-eral-week-long steroid treatment with Testosterone enanthate. Those who cannot wait until the depot steroids become effective inject 250 mg of Testosterone enanthate and 50 mg of Testosterone propionate at the beginning of the treatment. After two days, when the effect of the propionates decreases, another 50 mg ampule is injected. Two days after that, the elevated testosterone level caused by the propi-onate begins to decrease. By that time, the effect of the enanthates in the body would be present; no further propionate injections would be necessary. Thus the athlete rapidly reaches and maintains a high testosterone level for a long time due to the depot testo. This, for example, is important for athletes who with Anadrol 50 over the six-week treatment have gained several pounds and would now like to switch to testosterone. Since Anadrol 50 begins its "breakdown" shortly after use of the compound is discontinued, a fast and el-evated testosterone level is desirable.

The second option is to take propionate during the entire period of intake. This, however, requires a periodic injection every second day. Best results can be obtained with 50-100 mg per day or every sec-ond day. The athlete, as already mentioned, will experience visibly lower water retention than with the depot testosterones so that propionate is well-liked by bodybuilders who easily draw water with enanthate. A good stack for gaining muscle mass would be, for example, 100 mg Testosterone propionate every 2 days, 5p mg Winstrol Depot every 2 days, and 30 mg Dianabol/day. Propionate is mainly used in the preparation for a competition and used by female athletes. And in this phase, dieting is often combined with, testosterone to maintain muscle mass and muscle density at their maximum. Propionate has always proven effective in this regard since it fulfills these requirements while lowering possible water re-tention. This water retention can be tempered by using Nolvadex and Proviron. A combination of 100 mg Testosterone propionate every 2 days, either 50 mg Winstrol Depot/day or 76 mg Parabolan every 2 days, and 25 mg Oxandrolone/day help achieve this goal and are suitable for building up "quality muscles."

Women especially like propionate since, when applied properly, an-drogenic-caused side effects can be avoided more easily The trick is to increase the time intervals between the various injections so that the testosterone level can fall again and so there is an accumulation of androgens in the female organism. Women therefore take propi-onate only every 5-7 days and obtain remarkable results with it. The, androgenic effect included in the propionate allows better re-generation without virilization symptoms for hard-training women. The dosage is usually 25-50 mg/injection. Higher dosages and more frequent intervals of intake would certainly show even better re-sults but are not recommended for women. The duration of intake should not exceed 8-10 weeks and can be supplemented by taking mild and mostly anabolic steroids such as, for example, Primobolan, Durabolin, and Anadur in order to promote the synthesis of pro-tein. Men who do not fear the intake of testosterone or the possible side effects should go ahead and give propionate a try. The side ef-fects of propionate are usually less frequent and are less pronounced. The reason is that the weekly dose of propionate is usually much lower than with depot testosterones. A daily injection of 50 mg amounts to a weekly dose of 350 mg while several depot injections easily launch the milligram content of testosterone into the four-figure range. When compared with enanthate and cypionate, pro-pionate is also a "milder" substance and thus better tolerated in the body. Those who are convinced that they need daily testosterone injections should consider taking propionate. The key to suc-cess with propionate lies in the regular intake of relatively small quantities (50-100 mg every 1-2 days.)

Although the side effects of propionate are similar to the ones of enanthate and cypionate these, as already mentioned, occur less fre-quently. However, if there is a predisposition and very high dosages are taken, the known androgenic-linked side effects such as acne vulgaris, accelerated hair loss, and increased growth of body hair and deep voice can occur. An increased libido is common both in men and women with the use of propionate. Despite the high conversion rate of propionate into estrogen gynecomastia is less common than with other testosterones. The same is true for possible water reten-tion since the retention of electrolytes and water is less pronounced. The administration of testosterone-stimulating compounds such as HCG and Clomid can, however, also be advised with propionate use since it has a strong influence on the hypothalamohypophysial tes-ticular axis, suppressing the endogenous hormone production. The toxic influence on the liver is minimal so that a liver damage is unlikely (see also Testosterone enanthate). What athletes dislike most about propionate are the frequent injections that are necessary.

Doses: 100mg ED or EOD
Side effects: medium
Stack: Great for cut up cycle with Winstrol, EQ, Trenbolone

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SUSTANON - Testosterone blend

Substance: Testosterone propionate 30 mg, Testosterone phenylpropionate 60mg, Testosterone isocaporate 60 mg, Testosterone decanoate 100 mg

Sustanon is a very popular steroid which is highly appreciated by its users since it offers several advantages when compared to other testosteron compounds. Sustanon is a mixture of four different testosterones which, based on the well-timed composition, have a synergetic effect. This special feature has two positive characteristics for the athlete. First, based on the special combination effect of the compounds, Sustanon, milligram for milligram, has a better effect than Testosterone enanthate, cypionate, and propionate alone. Second, the effect of the four testosterones is time-released so that Sustanon goes rapidly into the sytem and remains effective in the body for several weeks. Due to the propionate also included in the steroid, Sustanon is effective after one day and, based on the mixed in decanoates, remains active for 3-4 weeks. Sustanon has a distinct androgenic effect which is coupled with a strong anabolic effect. Therefore it is well suited to build up strength and mass. A rapid increase in body strength and an even increase in body weight occur. Athletes who use Sustanon report a solid muscle growth since it results in less water retention and also aromatizes less than either testosterone enanthate or cypionate. Indeed many bodybuilders who use testosterone and fight against distinct water retention and an elevated estrogen level prefer Sustanon over other long-acting depot testosterones.


It is further noticed that Sustanon is also effective when relatively low doses are given to well advanced athletes. It is interesting to note that when Sustanon is given to athletes who have already used this compound in the same or lower doses, it leads to similar good results as during the previous intake. Sustanon is usually injected at least once a week., which can be stretched up to 10 days. The dosage in bodybuilding and powerlifting ranges from 250 mg every 14 days up to 1000 mg or more per day. Since such high dosages are not recommended and fortunately are also not taken in most cases the rule is 250-1000 mg/week. A dosage of 500 mg/week is completely sufficient for most, and can often be reduced to 250 mg/week by combining with an oral steroid. Sustanon is well tolerated as a basic steroid during treatment which stimulates the regeneration, gives the athlete a sufficient "kick" for intense training units, and next to the already mentioned advantage rapid strength increase and solid muscle gain distinguishes itself also by its compatibility. In order to gain mass fast Sustanon is often combined with Deca Durabolin, Dianabol (D-bol) or Anadrol while athletes who are more into quality prefer combining it with Parabolan, Winstrol,Anavar or Primobolan Depot.


Although Sustanon does not aromatize excessively when taken in a reasonable dosage many people, in addition, also take an antiestrogen such as Nolvadex and/or Proviron to prevent possible estrogen-linked side effects. Since Sustanon suppresses the endogenous testosterone production the intake of HCG and Clomid must be considered after six weeks or at the end of treatment. It is recommended that women not take depot testosterones since the androgen level would strongly increase and virilizalion syniploins could result. Despile this, it is not uncommon for female competing athletes in the higher weight classes to take testosterone since it helps in remaining "competitive." Women who use "Testo" or who would like to try it should limit its use to either only testosterone propionate or inject a maximum of 250 mg Sustanon every 10-14 days over a period of no longer than six weeks. At this point we would like to emphasize once more that steroid novices should stay away from all testosterone compounds since, at this time, they simply do not need them.


The side effects of Sustanon are similar to those of Testosterone enanthate (see also Testosterone enanthate) only that they are usually less frequent and less severe. Depending on the predisposition and dosage, the user can experience the usual androgenic-liked side effects such as acne, aggressiveness, sexual overstimulation, oily skin, accelerated hair loss, and reduced production of the body's own hormones. Water retention and gynecomastia are usually within limits with the "Sustas" or are not as massive as with enanthate and cypionate. Liver damage is unlikely with Sustanon however, in very high dosages, elevated liver values can occur which, after discontinuing use of the compound, usually go back to normal.

Understanding Sustanon 250

Sustanon 250 is a combination of testosterone propionate, testosterone phenylpropionate, testosterone isocaproate and testosterone decanoate. One of the most common myths about Sustanon 250 is that the combination of testosterone esters wields a pronounced, synergistic effect and thus has been highly sought after. Being that testosterone esters work in the same manner, largely by increasing protein synthesis, stimulating androgen receptors and suppressing cortisol levels, a synergistic effect between different testosterone esters is a myth with no basis. However the blend of “fast” and “slow” acting testosterones can be of benefit an athlete looking for an immediate response followed by a steady testosterone release. Testosterone propionate and testosterone phenylpropionate have been shown to produce notable testosterone elevations within hours of injection however peak blood testosterone levels plummet sharply after the second day. Testosterone isocaproate and testosterone decanoate function limitedly for approximately 3 and 4 weeks after their peak, starting the 3rd and ending the 7th day.

Milligram for milligram one would need to take at least one milliliter of Sustanon 250 every 2-3 days to compare to the long term gains of the same dosage of longer lasting testosterone esters like ICN and test. cypionate.

Keep in mind that esterification of testosterone merely slows its release into the blood stream. In other words there is no difference in the level of aromitization (estrogen conversion) or quality mass and strength gain between the many different testosterone esters. The characteristics of some common esters are as follows:

Testosterone Propionate:
Very fast acting, peak levels of this ester can be noted in the first 24 hours. However blood testosterone levels can diminish by 2/3 on the third day after injection. There is also a bit of discomfort associated with testosterone propionate; this is due to an allergic reaction to the propionate ester.

Sustanon 250:
Quick acting but unless taken every 2 or 3 days the testosterone propionate and testosterone phenylpropionate cannot be considered into the gross testosterone dosage as the fast acting esters will have severely diminished by the third and fourth day.

Testosterone Enanthate:
Peak levels of this ester are almost identical to testosterone cypionate. Identical to the point that any difference noticed between the two would be purely psychological.

Testosterone Cypionate:
Peak levels of blood testosterone are not noted until approximately the 3rd day and begin to decline rapidly by the 5th day. Testosterone cypionate can remain active, to a degree, for as long as 4 weeks.

There are many other esterfied forms of testosterone currently available on the black market most of which are long lasting esters.

Side effects:
The side effects associated with esterfied forms of testosterone are the same with all testosterone compounds because (as previously stated) a specific esterification dictates the speed that the testosterone will be released into the blood stream but the active compound is testosterone in each case.

Doses: 500 mg - 1000 mg a week
Side effects: Medium
Strength & Mass gains: Good
Stack: Good for mass in combination with Deca, EQ, Fina, A-bombs...

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DECA DURABOLIN - Nandrolone Decanoate

This is an injectable steroid that is a derivative of 19-nortestosterone. It is a favorite to thousands of steroid users. Deca is a low androgenic steroid, with high anabolic properties. It is excellent for developing size and strength. It does not have very little liver toxicity nor does it disturb the body’s own hormone functions excessively. Deca will aromatize in high dosages, but not at the rate of testosterone’s or other high androgenic compounds. This drug can be used for cutting or for bulking. Athletes have stacked it with virtually every drug and come out with positive results. It is a good base drug on any cycle. Deca can be used by almost all athletes and give positive results while presenting very few side effects. Women use this drug but only in very low dosages; 50 mg per week. Deca has been established as a great soother of sore joints and tendons. Athletes report that sore shoulders, knees, and/or elbows are somehow without pain on the Deca cycle. This may be substantiated by proving it reduces the amount of cortisol getting into muscle tissue during the cycle. Deca also dramatically improves nitrogen retention and recuperation time between workouts. Deca also dramatically improves nitrogen retention and recuperation time between workouts. Deca has shown up positive on more steroid tests than any other steroid. This is due to the fact that so many athletes use it, and that it stays in the system at a detectable level for up to a year. The drug itself is effective for about two weeks. Average dosages of this drug are from 200 - 400 mg per week for men. Deca used to be the most available drug on the black market, but it is fading fast. It is still available legitimately under the LyphoMed name, as well as Organon, Ruby and Steris, to name the most common labels.

Deca can come in many different strengths: 25, 50, 100, and 200 mgs/cc varieties., no oral versions of Deca produced. Deca-Durabolin is probably the all time most popular steroid (except for maybe Dianabol if you could actually find some). Deca produces very few side effects. It is easy on the liver and promotes good size and strength gains while reducing body fat.

Deca-Durabolin is highly anabolic and only moderately androgenic. It works by promoting a positve nitrogen balance in the body which causes the muscles to be able to use more protein, more efficiently than normal. It does this by causing the muscle cells to store more nitrogen than they are releasing. With this positive nitrogen balance, the muscle cells will be able to use more protein than they usually can. If you don't eat and sleep enough though, the magic will not happen.

It takes three days after injection to dissipate from the site and stays active in the body for about 17 days. Gains will go away very slowly after the cycling period if workouts are kept intense. Deca is the worst steroid that you can take if you run the chance of being drug tested. People have been known to test positive up to 1 1/2 years after the last shot. This is a very long time. Keep this in mind if you are in the NCAA or some other organization where you run the risk of being tested.

Side Effects
Deca-Durabolin is a relatively safe steroid. Typically, you can expect a little minor acne, higher blood pressure which causes a longer time period for blood to clot, headaches, and increased libido. Any of the following are also possible though: nausea, leukopenia, symptoms resembling a peptic ulcer, acne, edema (water retention), excitation (commonly referred to as roid rage), sleeplessness, chills, vomiting, diarrhea, hypertension, prolonged blood clotting time, increase in libido. Females had reported: menstrul irregularities, post-menopausal bleeding, swelling of the breasts, hoarseness or deepening of the voice, enlargement of the clitoris, and water retention. Men had reported: cases of impotence, chronic priapism, epididymitis, inhibition of testicular function, oligospermia, and bladder irritability.

Doses:400 mg - 600 mg a week
Side effects: None or minimum
Strength & Mass gains: Medium but solid
Stack: Great for mass in combination with any test, D-bols, A-bombs

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EQUPOISE - Boldenone Undecylenate

Is a very popular steroid and is only available legally at a veterinarian clinic. Boldenone is a highly anabolic, moderately androgenic steroid. For this very reason, it is typically taken in a stack with other steroids like testosterone if you are on a mass cycle or perhaps with winstrol if you are on a cutting cycle. The main benefit of taking equipoise is that it increases protein synthesis in the muscle cells. This effect is very similar to what you would experience while taking anavar. Boldenone gives you slower but much more high quality gains in muscle as opposed to the normal "quick" muscle gains that you would expect from a testosterone. This is not a steroid to take on its own and expect 20 lbs. in 6 weeks. It is just not going to happen. You can expect around 3 weeks before you start seeing results and they are not going to be staggering, but will be "more permanent" than any gains you would get from any of the multiple testosterones that are available. This steroid stays active in the system longer than most of the testosterones as well. This makes equipoise a poor choice if you run the possibility of being drug tested.

Boldenone is very common in the precontest arena for two main reasons. First off, there is a low amount of aromitization and secondly there is very little water retention while taking equipoise. This makes equipoise a good precontest steroid. Boldenone is well known to give a good increase in the pumps you get while working out. This is caused from the increase in red blood cells that you will experience while taking this steroid. It is also well known to help cause a dramatic increase in appetite. When taken with a good mass building steroid like dianabol, this is a sure formula for successful gains in muscle mass.

Doses: 200 - 500 mg/ week
Side effects: none
Strength & Mass gains: Solid
Stack: Great for mass in combination with Susta, ICN
Cutting: Good in combination with Primobolan depot or Winstrol

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WINSTROL DEPOT - Stanozolol

Winstrol Depot, however, is not only especially suited during preparation for a competition but also in a gaining phase. Since it does not cause water retention rapid weight gains with Winstrol Depot are very rare. However a solid muscle gain and an overproportionally strong strength increase occur, usually remaining after use of the compound is discontinued. Bodybuilders who want to build up strength and mass often combine Winstrol Depot with Dianabol, Anadrol 50, Testosterone, or Deca-Durabolin. With a stack of 100 mg Anadrol 50/day, 50 mg Winstrol Depot/day, and 400 mg Deca-Durabolin/week the user slowly gets into the dosage range of ambitious competing athletes. Older athletes and steroid novices can achieve good progress with either Winstrol Depot/Deca-Durabolin or Winstrol Depot/Primobolan Depot. They use quite a harmless stack which normally does not lead to noticeable side effects. This leaves steroid novices with enough room for the "harder" stuff which they do not yet need in this phase Winstrol Depot is mainly an anabolic steroid with a moderale, androgenic effect which, however
can especially manifest itself in women dosing 50 mg/week and in men dosing higher quantities. Problems in female athletes usually occur when a quantity of 50 mg is injected twice weekly. The effect of Winstrol Depot decreases considerably after a few days and thus an injection at least twice weekly isjustitied. However, an undesired accumulation af androgens in the female urganism can occur, resulting in masculinization symptoms. Some deep female voices certainly originated with the intake of Winstrol Depot. However, a dose of 50 mg Winstrol Depot every second day in ambitious female athletes is the rule rather than the exception. Other non-androgenic side effects can occur in men as well as in women, manifesting themselves in headaches, cramps, changes in the HDL and LDL values, and in rare cases, in high blood pressure. Possible liver damage can be estimated as very low when Winstrol is injected; however in large doses an elevation in the liver values is possible. Since Winstrol Depot is dissolved in water the injections are usually more uncomfortable or more painful than is the case with oily solutions.


Although there are many fakes of the injectable Winstrol, the original "Winny" as it is lovingly called by its users, is easily recognized based on its unusual form of administration. At a first glance the content of the ampule is only a milky, white, watery solution which, however has distinet characteristics. Original "Winny" is recognized because the substance separates from the watery injection fluid when the ampule is not shaken for some time. When the ampule is left flat in its ampule box or, for example, stands upright on a table, the substance accumulates as a distinctly visible white layer on the lower side of the glass and can only be mixed with the watery fluid if shaken several times or rolled forward and backward. An ampule containing 1 ml of suspension and its 50 mg dissolved stanozolol should normally separate a white layer in the size of almost a thumbnail. The athlete thus can easily determine whether his injectable Winstrol is actually stanozolol or is rather underdosed. Do not buy ampules or glass vials which contain more than 1 ml of suspension since an original injectable Winstrol is only available in one-milliliter glass ampules. The original Spanish ampules by Zambon have an unusually large round shape and a brown imprint. In the meantime there are several well-made fakes. The Italian ampules by Zambon can also be easily recognized since this is a small push-through ampule which has a large round shape and comes with a blue imprint. The imprint on the Italian and Spanish Winnies can be felt well with your fingernail. Faked stanozolol usually comes in commercial, narrow ampules.

When injected daily Winstrol Depot can become a very expensive compound. It also has the disadvantage that, because of the frequent injections, the already-mentioned scar tissue will develop in the gluteal region (buttocks) which leads many athletes to inject Winstrol in their shoulders, arms, legs or even calms.
Although this was originally intended as an expedient, injecting Winstrol Depot into certain muscles has become increasingly popular since athletes have noticed that this leads to an accelerated growth of the affected muscle. An American pro bodybuilder who is known for his cross-striated, horseshoe-shaped triceps owes this in considerable part to his regular "triceps Winstrol-Depot injections." A confusion with the also often used Esiclene is excluded. Athletes who want to avoid daily injections usually take 2-3ml Winstrol Depot twice a week. In the U.S. injectable stanozolol is manufactured only for veterinary medicine. It is distributed under the name Winstrol V by Winthrop and Upjohn Companies Unfortunately there are several fakes of Winstrol Depot. In the meantime, the chances of finding the Spanish or Italian Winslrol in the U.S. are quite high.

Doses: 200 - 400 mg/ week
Side effects: none
Strength & Mass gains: Solid and just pure mass
Cutting: Good in combination with Primobolan depot or Propio, Tren. EQ

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TRENBOLONE ACETATE

While Finaject itself is no longer available, in some cases injectable preparations from Finaplix have been made. The substance is the same: trenbolone acetate.

Trenbolone is a steroid having the advantages of undergoing no adverse metabolism, not being affected by aromatase or 5alpha-reductase; of being very potent Class I steroid binding well to the androgen receptor; and having a short half life, probably no more than a day or two though I don't believe this has been measured. Fifty milligrams per day is a good dosing for someone on his first cycle or someone who is as yet less than, say, 20 pounds over his natural limit; while 100 mg/day may be preferred by the more advanced user who has already gained more than this. These doses are assuming that trenbolone is the only Class I steroid being use. There really is no need to stack another -- testosterone being the only sensible exception -- but if another is stacked then the amount of trenbolone may be reduced accordingly.

There is no evidence in the literature, nor I think practical evidence, that trenbolone acetate has a "special role" in burning fat. Rather, it is an extraordinarily potent AAS, being about three times as effective per milligram as testosterone esters. This seems to apply only to Class I activity, however. To obtain good anabolism from non-AR-mediated mechanisms, a Class II steroid such as Dianabol or Anadrol should be stacked.

There used to be a myth that trenbolone was "hard on the kidneys." I have found no indication in the scientific literature of particular kidney toxicity with trenbolone. I know a number of users, at doses of 50-100 mg/day, who have experienced no problems. It seems to me that the claims that have been made were from athletes stacking an incredible amount of drugs, and how the blame could have fairly been laid at trenbolone (actually at Parabolan, not trenbolone acetate) is not clear.

It is also not clear that trenbolone results in any greater degree of increased aggression for a given amount of anabolic effect than testosterone itself does, despite another myth to that effect. The increase in aggressive tendency -- which does not mean the act of aggression -- is moderate and entirely controllable, if noticeable at all.

Trenbolone is a steroid having the advantages of undergoing no adverse metabolism, not being affected by aromatase or 5alpha-reductase; of being very potent Class I steroid binding well to the androgen receptor; and having a short half life, probably no more than a day or two. Fifty milligrams per day is a good dosing for someone on his first cycle or someone who is as yet less than, say, 20 pounds over his natural limit; while 100 mg/day may be preferred by the more advanced user who has already gained more than this. These doses are assuming that trenbolone is the only Class I steroid being use. There really is no need to stack another -- testosterone being the only sensible exception -- but if another is stacked then the amount of trenbolone may be reduced accordingly.

Since Finaject is the acetate form of trenbolone, its effect lasts only a short time and frequent administration is necessary. Most athletes inject I ml (30 mg) every second day. Higher dosages such as, for example, 30 mg/day or 60 mg every two days, however, were not unusual since an enormous strength gain and also a strong but still high-quality muscle gain was obtained.

Finaject does not aromatize since its substance is not changed into estrogens. In combination with Winstrol it has a dramatic effect on the body's appearance. To achieve a gigantic strength gain bodybuilders used to combine 30 mg Finaject every 1-2 days and 50 mg Winstrol Depot every 1-2 days (also known as Strombaject) during preparation for a competition and the buildup phase. No other combination gives the athlete such an incredible hardness and such a defined muscle gain. The possible physical change obtainable in only a few weeks is enormous enough to shock some non-involved observers. Believe us, competing bodybuilders love this combination especially.

Finaject was also part of probably the most effective stack for mass buildup. Together with Dianabol or Anadrol 50, and testosterone, "Fina" builds up strength and mass in record time. Another way of administration which is far less dangerous, can be prepared as follows: the ground pellets are mixed with a mixture of 50% water and 50% DMSO (dimethyl sulfoxide). Then the mixture is put on the skin and allowed to soak in. Dimethyl sulfoxide is used to transport the substance trenbolone through the skin. Using this method approximately 40 mg of the substance can get into the blood without much harm.

Doses: 50 - 100 mg/ED or EOD
Side effects: Medium
Strength & Mass gains: Solid
Stack: Great for pure mass in combination with any test
Cutting: Good in combination with Primobolan depot or Winstrol

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DIANABOL - Methandrostenolone

Dianabol, Ciba's old brand name for 5mg Methandrostenolone tablets, has always been one of the most popular anabolic steroids available. Dianabol's popularity stems from it's almost immediate and very strong anabolic effects. 4-5 tablets a day is enough to give almost anybody dramatic results. Along with strong anabolic effects comes the usual androgen side effects. Dianabol converts to estrogen, so gyno and water retention may be a problem although are usually dose related Aggression may be increased, and users often report an overall sense of well being. The fact that Dianabol has been off the U.S. market for almost 10 years has not at all stopped its use and remains the most popularly used black market oral steroid in the U.S.. The most popular versions in the U.S. are the Russian tablets coming into the East Coast, Pronabol from India and Reforvit from Mexico. The Russian Dianabol, which is vastly and accurately counterfeited, has been losing it's reputation as a safe buy. Users generally won't know if what they have is real until they use it, making for many angry users. Reforvit is an injectable D, containing 25mg/ml of the substance. A 50 ml bottle contains the equivalent of 250 tablets and sells for a reasonable price. Most users opt to take this orally as it is just as effective as tablets. The pink Thai tablets are also popular and should be the only tablets purchased without paperwork or box. These ship in quantities of 500 and 1000 only, so they are almost always broken up and sold. Methandon is also available in Thailand, but much less popular than the Anabol tabs.

Methandrostenolone was a very popular drug in the 70´s, and still is. It is a 17 alpha-alkyl based steroid which produces dramatic strength and size gains. This is also a very toxic drug.

Dianabol is an orally applicable steroid with a great effect on the protein metabolism. It promotes the protein synthesis, thus it supports the buildup of protein. This gives the athlete a positive nitrogen balance and an improved well-being. The calcium uptake is also increased, thus promoting calcium deposits in the bones. Dianabol was introduced on the market in 1960, and within a short period of time, became the most favoured, and most used anabolic. Dianabol has a very strong anabolic and androgenic effect, which manifests itself in an enormous buildup of strength and muscle mass in its users. It's analysis of a 'mass' steroid, is thus, justified. The compound works quickly and reliably, with gains of 2-4 pounds per week in the first six weeks widely reported. The additional bodyweight consists of a true increase in muscle tissue, and in particular, a noticeable retention of fluids. Dianabol aromatizes easily, so that the simultaneous administration of an anti-estrogen, such as Nolvadex or Proviron, is wise. For this reason, it is rarely used as a competition steroid. The dosage spectrum is very wide, with athletes taking between two, and twenty tablets a day. However, what is worth noting is the statement that Ciba-Geigy made on their products container; "There seems to be NO direct correlation between the increase of body weight and the amount of the dosage." Also, another statement by 'Hormonelle Regulation', confirms this, by saying; "A simple correlation between the administered dosage and the amount of concentration in the blood could not be found either."

Accordingly, an effective daily dose for athletes is around 15-40mg/day (ie.3-8tabs). Steroid novices do not need more than 15-20mg per day since this dose is sufficient to acheive exceptional results over a period of 8-10 weeks. When the effect begins to slow down (mostly due to the steroid receptors being saturated at this time, subsequently cannot hold any more of the compound), and the athlete wants to continue, the dosage should NOT be increased, but an injectable such as Deca-Durabolin or Primabolan-Depot 200mg / week should be used in conjunction until the athlete slowly tapers off the Dianabol. Dan Duchane was once quoted by saying; "If you can't grow on Deca and D-bol, then you're not going to grow anything, no matter how fancy it is."

Since Dianabol's half time life is only 3.2-4.5 hours, application at least twice a day is necessary to acheive a somewhat even concentration of the substance in the blood. On days of intense training, the half time life is reduced even further, so the application of three times per day appears sensible. Since Dianabol is also 17-alpha alkylated, and thus largely protected against a loss in effect, it is recommended that the tablets be taken during meals so that possible gastrointestinal pains can be avoided. Interestingly, on the third day after discontinuing Dianabol, proof of the substance in the blood is negative. This is how athletes avoid positive drug tests. The maximum substance concentration of Dianabol reaches the blood after 1-3 hours. A simple application of only 10mg results in a 5-fold increase in the average testosterone concentration in the male. Why Dianabol works so well in ALL athletes, is the the endogenous cotisone production is reduced by 50-70%. Thus, Dianabol considerably reduces the rate at which protein is broken down in the muscle cell. Although Dianabol has many potential side effects, they are rare with a dosage of up to 20mg/day. Since Dianabol is 17-alpha alkylated, it causes a considerable strain on the liver. In high dosages, and over a longer period of time, dianabol is liver toxic. Even a dosage of 10mg/day can increase the liver values, however, after discontinuation, the values return to normal.

Dianabol is still one of the most effective strength and size building oral steroid. It causes considerable water retention and aromatizes quite a bit so you`ll see quite a bit of dosage jumps while using it. Available over the counter in Mexico with no prescription needed. People get good results with Dianabol. Dianabol is now available under its generic name of Methandrostenelone and is being produced domestically by Rubu Labs. Originally, Dianabol came in 50 mgs tablets. It was developed in the mid-forties and experimentally used on returning prisoners of war that had been on very low food intakes. Actual dosages of the generally available 5 mg (it also comes in 2,5 mgs tablets) many doctors prescribe a 4 day with 8 to 10 the average for self-made expert and 100 is not unheard of in one day. The generic version may be the best price if Anadrol keeps rising in price. Not many women use it because it is high in androgens. Some people report sleeplessness with high dosages

Doses: 5-10 tablets a day (5 mg tablets)
Side effects: Medium
Strength & Mass gains: Good and quite solid!
Stack: Great for mass in combination with any test, D-bols, EQ

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ANAVAR - Oxandrolone

Searle Company introduced the substance oxandrolone to the U.S. market in 1964 under the name Anavar and it enjoyed great popu-larity for over two decades until, on July 1, 1989, the produc-tion of Anavar was phased out. Today Anavar is manufactured under its various generic names in only a few countries (see above). The compound with the generic name Oxandrolone SPA by S.p.A. Milano Company (Società Prodotti Antibiotica) from Italy is the only original anabolic steroid available in Europe which contains the substance oxandrolone. There are 30 tablets in one box with two push-through strips of 15 tablets each.

Oxandrolone is a weak steroid with only a slight androgenic component. It has been shown that Oxandrolone, when taken in reasonable dos-ages, rarely has any side effects. This is appreciated since Oxandrolone was developed mostly for women and children. Oxandrolone is one of the few steroids which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason Oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Oxandrolone a fa-vored remedy for female athletes since, at a daily dose of 10-15 mg, masculinizing symptoms are observed only rarely.

Bodybuilders and powerlifters, in particular, like Oxandrolone for three reasons. First, Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing liquid (water) in the joints and the muscles. Powerlifters and weightlifters who do not want to end up in a higher weight class take advantage of this since it allows them to get stronger without gaining body weight at the same time. The combination of Oxandrolone and 20 - 30 mg Holotestin daily has proven to be very effective since the muscles also look harder. Similarly good results can be achieved by a simultaneous intake of Oxandrolone and 120-140 mcg Clenbuterol per day. Although Oxandrolone itself does not cause a noticeable muscle growth it can clearly improve the muscle-developing effect of many ste-roids. Deca-Durabolin, Dianabol, and the various testosterone compounds, in particular, combine well with Oxandrolone to achieve a "mass buildup" because the strength gain caused by the intake of these highly tissue-developing and liquid-retaining sub-stances results in an additional muscle mass. A stack of 200 mg Deca-Durabolin/week, 500 mg Testosterone enanthate (e.g. Testoviron Depot 250)/week, and 25 mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca-Durabolin has a distinct anabolic effect and stimulates the syn-thesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis; and Testosterone enanthate increases the aggressiveness for the workout and accelerates regeneration.

The second reason why Oxandrolone is so popular is that this compound does not aromatize in any dosage. As already men-tioned, a certain part of the testosterone present in the body is converted into estrogen. This aromatization process, depending on the predisposition, can vary distinctly from one athlete to another. Oxandrolone is one of the few steroids which cannot aromatize to estrogen. This characteristic has various advantages for the athlete. With Oxandrolone the muscle system does not get the typical watery appearance as with many steroids, thus making it very interesting during the preparation for a competition. In this phase it is especially important to keep the estrogen level as low as possible since estrogen programs the body to store water even if the diet is calorie-reduced. In combination with a diet, Oxandrolone helps to make the muscles har~ and ripped. Although Oxandrolone itself does not break downfat, it plays an indirect role in this process because the substancr-often suppresses the athlete's appetite. Oxandrolone can also cause some bloating which in several athletes results in nausea and vomiting when the tablets are taken with meals. The package insert of the Italian Oxandrolone notes its effect on the activity of the gas-trointestinal tract. Some athletes thus report continued diarrhea. Although these symptoms are not very pleasant they still help the athlete break down fat and become harder. Those who work out for a competition or are interested in gaining quality muscles should combine Oxandrolone with steroids such as Winstrol, Parabolan, Masteron, Primobolan, and Testosterone propionate. A stack of 50 mg Winstrol every two days, 50 mg Testosterone propionate every two days, and 25 mg Oxandrolone every day has proven effective. Another advantage of Oxandrolone's non-aromatization is that athletes who suffer from high blood pres-sure or develop gynecomastia of the thymus glands when taking stronger androgenic steroids will not have these side effects with this compound. The. Oxandrolone/Deca-Durabolin stack is a wel-come alternative for this group of athletes or for athletes show-ing signs of poor health during mass buildup with testosterone, Dianabol, or Anadrol 50. Athletes over forty should predomi-nantly use Oxandrolone.

The third reason which speaks well for an intake of Oxandrolone is that even in a very high dosage this compound does not influ-ence the body's own testosterone production. To make this clear: Oxandrolone does not suppress the body's own hormone pro-duction. The reason is that it does not have a negative feedback mechanism on the hypothalamohypophysial testicular axis, meaning that during the intake of Oxandrolone, unlike during the intake of most anabolic steroids, the testes signal the hypo-thalamus not to reduce or to stop the release of GnRH (gonadot-ropin releasing hormone) and LHRH Luteinizing hormon releas-ing hormone). This special feature of Oxandrolone can be explained by the fact that the substance is not converted into estrogen Oxandrolone (Anavar), when given to normal men in high doses does not reduce the seminal volume or count, nor can it be converted (aromatized) into estrogen.

Oxandrolone combines very well with Andriol, since Andriol does not aromatize in a dosage of up to 240 mg daily and has only slight influence on the hormone production. The daily intake of 280 mg Andriol and 25 mg Oxandrolone re-sults in a good gain in strength and, in steroid novices, also in muscle mass without excessive water retention and without a significant influence on testosterone production. As for the dos-age of Oxandrolone, 8-12 tablets in men and 5-6 tablets in women seem to bring the best results. The rule of thumb to take 0.125 mg/pound of body weight daily has proven successful in clinical tests. The tablets are normally taken two to three times daily after meals thus assuring an optimal absorption of the substance. Those who get the already discussed gastrointestinal pain when taking Oxandrolone are better off taking the tablets one to two hours after a meal or switching to another compound.

Since Oxandrolone is only slightly toxic and usually shows few side effects it is used by several athletes over a prolonged period of time. However Oxandrolone should not be taken for several consecutive months, since, as with almost all oral steroids it is 1 7-alpha alky-lated and thus liver toxic. Oxandrolone is an all-purpose remedy which, depending on the athlete's goal, is very versatile. Women who react sensitively to the intake of anabolic steroids achieve good results when combining Oxandrolone/Primobolan Tabs and/or Clenbuterol, without suffering from the usual virilization symp-toms. Women, however, should not take more than 6 tablets daily. otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.

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ANADROL - Oxymetholone

Anadrol 50 is the strongest and, at the same time, also the most effective oral steroid. The compound has an extremely high andro-genic effect which goes hand in hand with an extremely intense anabolic component. For this reason, dramatic gains in strength and muscle mass can be achieved in a very short time.

For this reason, dramatic gains in strength and muscle mass can be achieved in a very short time. An increase in body weight of 10 - 15 pounds or more in only 14 days is not un-usual. Water retention is considerable, so that the muscle diameter quickly increases and the user gets a massive appearance within record time. Since the muscle cell draws a lot of water, the entire muscle system of most athletes looks smooth, in part even puffy. Anadrol does not cause a qualitative muscle gain but rather a quan-titative one which in the off-season is quite welcome. Anadrol "lu-bricates" the joints since water is stored there as well. On the one hand this is a factor in the enormous increase of strength and, on the other hand, it allows athletes with joint problems a painless workout. Powerlifters in the higher weight classes are sold on Anadrol. A strict diet, together with the simultaneous intake of Nolvadex and Proviron, can significantly reduce water retention so that a distinct increase in the solid muscles is possible. By taking Anadrol the athlete experiences an enormous "pump effect" during the workout in the exercised muscles. The blood volume in the body is significantly elevated causing a higher blood supply to the muscles during workout. Anadrol increases the number of red blood cells, allowing the muscle to absorb more oxygen. The muscle thus has a higher endurance and performance level. Consequently, the athlete can rely on great power and high strength even after several sets. The highly androgenic effect of Anadrol stimulates the regeneration of the body so that the often-feared "overtraining" is unlikely. Although Anadrol is not a steroid used in preparation for a compe-tition, it does help more than any other steroid during dieting to maintain the muscle mass and to allow an intense workout. Many bodybuilders therefore use it up to about one week before a compe-tition, solving the problem of water retention by taking antiestrogens and diuretics so that they will appear bulky and hard when in the limelight.

As for the dosage, opinions differ. A dosage sufficient for any athlete would be 0,5 - 0,8 mg per pound of body weight/day. This corresponds to 1-4 tablets; i.e. 50-200 mg/day. Under no circumstances should an athlete take more than four tablets in any given day. We are of the opinion that a daily intake of three tablets should not be exceeded. Those of you who would like to try Anadrol 50 for the first time should begin with an intake of only one 50 mg tablet. After a few days or even better, after one week, the daily dosage can be increased to two tab-lets, one tablet each in the morning and evening, taken with meals. Athletes who are more advanced or weigh more than 220 pounds can increase the dosage to 150 mg/day in the third week. This dos-age, however, should not be taken for periods longer than two to three weeks. Anadrol 50 should not exceed six weeks. After discontinuing Anadrol, it is important to continue ste-roid treatment with another compound since, otherwise, a drastic reduction takes place and the user, as is often observed, within a short period looks the same as before the treatment. No other ana-bolic/androgenic steroid causes such a fast and drastic loss in strength and mass as does Anadrol 50. Athletes continue their treatment with injectable testosterone such as Sustanon 250 or Testosterone enanthate for several weeks. Body-builders often combine Anadrol with Deca-Durabolin or Testoster-one to build up strength and mass. A very effective stack which is also favored by professionals consists of Anadrol 100 mg +/day, Parabolan 228 mg +/week, and 5ustanon 500 mg +/week. This stack quickly improves strength and mass but it is not suitable for and steroid novices. Anadrol 50 is to be taken seriously and the prevailing bodybuilder mentality "more is bet-ter" is out of place.

Anadrol 50 is unfortunately also the most harmful oral steroid. Its intake can cause many considerable side effects. Since it is I 7-alpha alkylated it is very liver-toxic. Most users can expect certain patho-logical changes in their liver values after approximately one week. An increase in liver values of both the enzymes GOT and GPT also called transaminases, often cannot be avoided. Elevated GOT and GPT values are indications of hepatitis, i.e. a liver infection. Those who discontinue oxymetholone will usually show normal values within two months. Longer intake and/or higher doses can cause a yellow discoloration of fingernails, eyes, or skin 0aundice). This is because oxymetholone induces an increase of biliburin in the liver, producing a bile pigment which causes the yellow discoloring of the skin. The liver enzyme gamma-GT also reacts sensitively to the oxymetholone, causing it to elevate. If high dosages of Anadrol 50 are taken over a long period, there is an increased risk that the de-scribed liver changes could end up damaging the liver. During the intake of Anadrol 50, the liver values, GOT, GPT, bilirubin, gamma--GT and alkaline phosphatase (AP), as well as the LDH/HBDH quo-tient, should always be checked by a competent physician. Anadrol 50 (representing all oxymetholone-containing steroid products) is the only anabolic/androgenic steroid which was linked with liver cancer.

The compound oxymetholone easily converts into estrogen. This causes signs of feminization (e.g. gynecomastia) and the already -mentioned water retention which in turn requires the intake of antiestrogens (e.g. Nolvadex and Proviron) and an increased use of diuretics (e.g. Lasix) before a competition. The increased water re-tention, in addition to the aesthetical problems, can be further detri-mental since it may cause high blood pressure. In extreme cases the intake of an anti-hypertensive drug, e.g. Catapresan, may be neces-sary. Since a substantial amount of the compound converts into dihydrotestosterone (DHT) in the body, it is possible that, with a given disposition, severe acne and an increased hair loss can occur. Bodybuilders who experience severe steroid acne caused by Anadrol can get this problem under control by using the prescription drug Accutane.

Other possible side effects may include headaches, nausea, vomit-ing, stomach aches, lack of appetite, insomnia, and diarrhea. The athlete can expect a feeling of "general indisposition" with the in-take of Anadrol which is completely in contrast to Dianabol which conveys a "sense of well-being". The increased aggres-siveness is caused by the resulting high level of androgen and occurs mostly when large quantities of testosterone are "shot" simulta-neously with the Anadrol. The body's own production of testoster-one is considerably reduced since Anadrol has an inhibiting effect on the hypothalamus, which in turn completely reduces or stops the release of GnRH (gonadotropin releasing hormone). For this reason the intake of testosterone-stimulating compounds such as HCG and Clomid is absolutely necessary to main-tain the hormone production in the testes.

Anadrol 50 is not recommended for women since it causes many and, in part, irreversible virilizing symptoms such as acne, clitorial hypertrophy, deep voice, increased hair growth on the legs, beard growth, missed periods, increased libido, and hair loss. Anadrol is simply too strong for the female organism and accordingly, it is poorly tolerated.

Doses: 1 - 3 tablets daily
Side effects: all possible
Strength & Mass gains: The best
Stack: Great for mass in combination with Sustanon, Enanthate

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PRIMOBOLAN DEPOT - Methenolone Enanthate

Primobolan Depot is an injectable steroid produced by Schering and sold in various parts of the world. It contains the steroid metenolone enanthate, which is a long acting anabolic with extremely low androgenic properties. The anabolic properties of this steroid also are mild. Primobolan is most commonly used during cutting cycles although some users do stack it with stronger drugs like testosterone and Dianabol for mass cycles. This drug is most commonly injected on a weekly basis and dosages range widely. At 100-200 mg weekly Primobolan should not interfere with natural testosterone levels and should not produce noticeable side effects. In Europe it is not uncommon for Primobolan to be used at such doses for long term therapy. Among athletes, steroid novices will respond to weekly doses of 200 mg but regular users often inject much higher doses looking for a stronger anabolic effect. Primobolan Depot comes in 1ml glass ampules containing 100mg of the drug in Europe and 50mg throughout areas of South America. In the U.S. the 50mg ampules from Mexico and 100mg ampules from Spain most commonly show up.

Primobolan Depot, although with a weaker effect than Deca-Durabolin, is a good basic steroid with a predominantly anabolic effect and, depending on the goal, can be effectively combined with almost any steroids. Those who would like to gain mass rapidly and do not have Deca available, can use Primo-Depot together with Sustanon 250 and Dianabol. Those who have more patience or are afraid of potential side effects will usually be very satisfied with a stack of Primobolan-Depot 200 mg/week and Deca-Durabolin 200-400 mg/week. We believe that the best combination is Primobolan Depot with Winstrol Depot. 200 - 400 mg/week is the normally used dosage of Primobolan Depot although there are enough athletes who inject a 100 mg ampule daily. Primobolan Depot, like the oral acetate form, is not converted into estrogen however, low water retention can occur, which is the reason why during preparalions for a competition the injections are usually preferred.


Side effects with Primobolan Depot are minimal and manifest themselves only rarely and in persons who are extremely sensitive. Due to the androgenic residual effect, side effects include light acne, deep voice or increased hair growth. Primobolan Depot has even less in fluence on the liver function than the oral form so that an increase of the liver's toxin values is extremely unlikely. The blood pressure, cholesterol level, HDL and LDL values, as with Primo tablets, usually remain unaffected. Primobolan Depot is generally the safest injectable steroid. Athletes whose liver values strongly increase when taking anabolic steroids but who still do not want to give up their use, under periodical supervision of these values, can go ahead and try a stack of Primobolan Depot, Deca-Durabolin, and Andriol. A well-known bodybuilder in Germany who had already won several national titles has admitted that his liver was damaged by his too frequent use of the 17-alpha alkylated steroids Dianabol, Anadrol 50 (at the time still Plenastril), and Oxandrolone. He was,however, able to bring his body back to national championship level by taking 200 mg Primobolan-Depot/week, 400 mg Deca- Durabolin/week, and 240 mg Andriol/day, without a negative effect on the liver values. Primobolan Depot, like the tablets, has only a very small influence on the hypothalamuhypophysiat testicular axis so that the body's own testosterone production is only reduced when very high dosages are taken over a prolonged period of time.

Doses: 300 mg a week minimum
Side effects: totally none
Cutting: Good
Stack: Great for cut up cycle with Winstrol, EQ, Fina

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MASTERON - Drostanolone Propionate

Masteron is a steroid highly valued by competing bodybuilders. The great popularity of this injectable steroid in bodybuilder circles is due to the extraordinary characteristics of its included substance. Drostanolone propionate is a synthetic derivative of dihydrotestosterone.

This causes the Masteron not to aromatize in any dosage and thus, it cannot be converted into estrogens. Since Masteron is a predominantly androgenic steroid, the athlete can increase his androgen level without also risking an increase in his estrogen level. This results in a dramatically improved hardness and sharpness of the muscles. One must, however, make a distinction here since Masteron does not automatically improve the quality of muscles in everyone. A prerequisite is that the athlete's fat content must already be very low. In this case Masteron can then be the decisive factor between a smooth, flat muscle or a hard and ripped look. For this purpose Masteron is often only used during the last four weeks before a competition so that the muscles get the last "kick." Masteron is especially effective in combination with steroids such as Winstrol, Parabolan, Primobolan, Oxandrolone and also Testosterone propionate.

The usual dosage taken by athletes is around 100 mg three limes per week. Since the substance drostanolone propionate is quickly broken down in the body, frequent and regular injections are neces-sary. This fact makes Masteron a very interesting steroid when dop-ing tests must be passed by a negative urine analysis. Since the pro-pionate substance of drostanolone does not remain in the body very long in a sufficient, detectable amount, athletes inject the com-pound with great success up to two weeks before a test. However, since it also has anabolic characteristics and thus helps the buildup of a high-qualitative muscle system, the use of Masteron is not only limited to the preparation stage for a competition. Athletes who want to avoid water retention and who readily have a problem with an elevated estrogen level, likewise appreciate Masteron. Also in this case usually one ampule (100 mg) is injected every second day. In combination with Primobolan, Winstrol or Testosterone pro-pionate no enormous strength and weight gains can be obtained, only high-quality and long-lasting results. Although women do not use Masteron very often some national and international com-peting female athletes do take it before a championship. The dosages observed are normally 100 mg every 4-5 days.

Masteron is not hepatoxic so liver damage is quite unlikely. High blood pressure and gynecomastia are not a problem since neither water nor salt retention occurs and the estrogen level remains low. The main problem are acne and a possible accelerated hair loss since dihydrotestosterone is highly affinitive to the skin's androgen re-ceptors, in particular, to those on the scalp. Since Masteron, in most cases, is not administered in excessively high dosages and the in-take, at the same time, is limited to a few weeks, the compatibility for the athlete is usually very good.

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NOLVADEX - Tamoxifen citrate

This remedy is somewhat different from others since it is not an anabolic/androgenic steroid. For male and female bodybuilders,however, it is a very useful and recommended compound which is confirmed by its widespread use and mostly positive results. Nolvadex belongs to the group of sex hormones and is a so-called antiestrogen. The normal application of Nolvadex is in the treatment of certain forms of breast cancer in female patients. With Nolvadex it is possible to reverse an existing growth process of deceased tissue and prevent further growth. The growth of certain tissues is stimulated by the body's own estrogen hormone. This is especially true for the breast glands in men and women since the body has a large number of estrogen receptors at these glands which can bond with the estrogens present in the blood. If the body's own estrogen level is unusually high an undesired growth of breast glands occurs. However, in healthy women and particularly in men this is not the case. Despite this, it is mostly male bodybuilders who use Nolvadex, and fewer women. At fiist sight this seems somewhat inconceivable but when taking a closer look, the reasons are clear. Bodybuilders who take Nolvadex also use anabolic steroids at the same time. Since most steroids aromatize more or less strongly, i.e. part of the substance is converted into estrogens, male bodybuilders can experience a significant elevation in the normally very low estrogen level. This can lead to feminization symptoms such as gynecomastia (growth of breast glands), increased fat deposits and higher water retention.


The antiestrogen Nolvadex works against this by blocking the estrogen receptors of the effected body tissue, thereby inhibiting a bonding of estrogens and receptor. It is, however, important to understand that Nolvadex does not prevent the aromatization but only acts as an estrogen antagonist. This means that it does not prevent testosterone and its synthetic derivatives (sleroids) from converting into estrogens but only fights with them in a sort of "competition''for the estrogen receptors. This characteristic has the disadvantage that after the discontinuance of Nolvadex a "rebound effect" can occur which means that the suddendly freed estrogen receptors are now able to absorb the estrogen present in the blood. For this reason the combined intake of Proviron is suggested (see Proviron. ) Nolvadex is also useful during a diet since it helps in the burning of fat. Although Nolvadex has no direct fatburning effect its antiestrogenic effect contributes to keeping the estrogen level as low as possible. Nolvadex should especially be taken together with the strong androgenic steroids Dianabol and Anadrol 50, and the various testosterone compounds. Athletes who have a tendency to retain water and who have a mammary dysfunction should take Nolvadex as a prevention during every steroid intake. Since Nolvadex is very effective in most cases it is no wonder that several athletes can take Anadrol 5O and Dianabol until the day of a competition, and in combination with a diruretic still appear totally ripped in the limelight. Those who already have a low body fat content will achieve a visibly improved muscle hardness with Nolvadex.


Several bodybuilders like to use Nolvadex at the end of a steroid cycle since it increases the body s own testosterone production which will be discussed in more detail in the following-to counteract the side effects caused by the estrogens. These can occur after the discontinuance of steroids when the androgen level in relationship to the estrogen concentration is too low and estrogen becomes the dominant hormone. A very rare but all the more serious problem of Nolvadex is. that. in some cases it does not lower the estrogen level but can increase it. The Canadian physician, Dr: Mauro G. DiPasquale,in his book Drug Use and Detection in Amateur Sports, Update Five confirms this possibility: "Recent studies have shown, however that in a small number of people taking tamoxifen, the effect can be paradoxical. Instead of decreasing estrogen production, it can promote it; and instead of acting as an estrogen antagonist it can act as an agent. In these cases, for some unknown reason, adrenal DHEA production is dramatically inereased. Since DHEA is a steroid precurser for peripheral estrogren (and testosterone) production, serum estrogen levels are increased and the higher serum levels overwhelm the tamoxifen which is binding to the central receptors. Apparently only a slight increase in the serum estrogen concentration is needed to overcome the anti-estrogen effects of tamoxifen."


Another disadvantage is that it can weaken the anabolic effect of, some steroids. The reason is that Nolvadex, as we know, reduces the estrogen level. The fact is, however, that certain steroids especially the various testosterone compounds-can only achieve their full effect if the estrogen level is sufficiently high. Daniel Duchaine in his book Ask the Guru bolsters this thesis: "But it (testosterone)is not anabolic in and of itself, because it reduires the body to have a sufficient level of estrogen in order to achieve its fullest anabolic effect. This is why there is reduced anabolic activity from many steroids when Nolvadex (an estrogen antagonist, which is used primarily to prevent gynecomastia) is added to a steroid stack." Those who are used to the intake of larger amounts of various steroids do not have to worry about this. Athletes however, who predominantly use mild steroids such as Primobolan, Winstrol, Oxandrolone, and Deca-Durabolin should carefully consider whether or not they should take Nolvadex since, due to the compound's already moderate anabolic cffect, an additional loss af effect could take place, leading to unsatisfying results.


A rarely observed but welcome characteristic of Nolvadex is that it has a direct influence on the hypothalamus and thus, by an increased release of gonadotropine, it stimulates the testosterone production in the testes. This does not result in a tremendous but still a measurable increase of the body's own testosterone. This effect, however, is not sufficient to significantly increase the testosterone production reduced by anabolic /androgenic steroids. Also the physician Dr. Mauro G. Di Pasquale whom we have mentioned several times writes in his book Anabolic Steroid Side Effects-Fact, Fiction and Treatment on page 29: "However these compounds seem to have little effect on preventing the suppression of the HPTH while anabolic steroids are being used, perhaps because of an over riding direct suppression exerted by the anabolic steroids on the HPTA." For natural bodybuilders, however, use of Nolvadex, in this context, should be worth considering.


The side effects of Nolvadex are usually low in dosages of up to 30 mg/day. In rare cases nausea, vomiting, hot flashes, numbness, and blurred vision can occur. In women irregular menstrual cycles can occur which manifest themselves in weaker menstrual bleeding or even complete missing of a period. Women should also be careful not to get pregnant while taking Nolvadex. It is important for female athletes that Nolvadex and the "pill" not be taken together since the antiestrogen Nolvadex and the estrogen-containing pill negatively countereffect each other.The normal daily dosage taken by athletes corresponds more or less to the dosage indications of the manufacturer and is 10-30 mg/day. To prevent estrogenic side effects normally 10 mg/day are sufficient, a dosage which also Keeps low the risk of reducing the effect of simultaneously-taken steroids. Often it is sufficient if the athlete begins this preventive intake of Nolvadex only three to four weeks after the intake of anabolics. Athletes who have tendencies toward gynecomastia, strong water retention, and increased fat deposits with steroids such as Dianabol, Testosterone, Anadrol 50, and Deca-Durabolin usually take 20-30 mg/day. The combined application of Nolvadex 20-30 mg/day and Proviron 25-50 mg/day in these cases leads to excellent results. The same is true for athletes who are in competition, and for women. Women, however should do without the intake of Proviron or at least reduce the dose to one 25 mg tablet per day. Unfortunately, in most cases, a very pronounced gynecomastia ("pregnant dog tits") cannot be reduced by taking Nolvadex so that often surgery is required, surgery which is not paid for by health insurance. First signs of a possible gynecomastia are light pain when touching the nipples. The tablets are usuall taken 1-2x daily, swallowed whole without chewing, with some liquid during meals.

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CLOMID - Clomiphene Citrate

Clomid is not an anabolic/androgenic steroid. Since it is a synthetic estrogen it belongs, however, to the group of sex hormones. In school medicine Clomid is normally used to trigger ovulation.

Clomid also has a strong influence on the hypothalamohypophysial testicular axis. It stimulates the hypo-physis to release more gonadotropin so that a faster and higher re-lease of FSH (follicle stimulating hormone) and LH (luteinizing hor-mone) occurs. This results in an elevated endogenous (body's own) testosterone level. Clomid is especially effective when the body's own testosterone production, due to the intake of anabolic/androgenic steroids, is suppressed. In most cases Clomid can normalize the tes-tosterone level and the spermatogenesis (sperm development) within 10- 14 days. For this reason Clomid is primarily taken after steroids are discontinued. At this time it is extremely important to bring the testosterone production to a normal level as quickly as possible so that the loss of strength and muscle mass is minimized. Even better results can be achieved if Clomid is combined with HCG or when Clomid is used after the intake of HCG.

Paradoxically, although Clomid is a synthetic estrogen it also works as an antiestrogen. The reason is that Clomid has only a very low estrogenic effect and thus the stronger estrogens which, for example, form during the aromatization of steroids, are blocked at the recep-tors. These would include those that develop during the aromatiz-ing of steroids. This does not prevent the steroids from aromatizing but the increased estrogen is mostly deactivated since it cannot at-tach to the receptors. The increased water retention and the possible signs of feminization can thus be reduced or even completely avoided. Since the antiestrogenic effect of Clomid is lower than those found in Proviron, Nolvadex, and Teslac it is mainly taken as a testosterone stimulant. Clomid is a medica-tion that promotes the production of the body's own stimulating hormone, gonadotropin, which in turn increases the testosterone level. It is, for example, administered to women as a so-called antiestrogen to trigger ovulation ("ovulation stimulator").

Side effects of Clomid are very rare if reasonable dosages are taken. Possible side effects are climacteric hot flashes and occasional visual disturbances which can manifest themselves in blurred vision, giv-ing flickering or flashing. Should visual disturbances occur, the manufacturer recommends discontinuing Clomid treatment. Inad-equate liver functions cannot be excluded; however, they are very unlikely. In women enlargement of the ovaries and abdominal pain can occur since Clomid stimulates the ovaries. When taking Clomid multiple pregnancies are possible as well. As for the dosage, 50-100 mg/day (1 -2 tablets) seems to be sufficient. The tablets are usually taken with fluids after meals. If several tablets are taken it is recom-mended that they be administered in equal doses distributed through-out the day. The duration of intake should not exceed 10 to 14 days. Most athletes begin with 100 mg/day, taking one 5 0 mg tablet ev-ery morning and evening after meals. After the fifth day the dosage is often reduced to only one 50 mg tablet per day It is normally not necessary to take the compound for more than ten days in order to increase the endogenous testosterone production. Since Clomid should not be taken for a prolonged time its application as an antiestrogen must be excluded because, for that purpose, it would have to be taken for several weeks.

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LETROZOLE - New Generation Anti-E

DESCRIPTION
Femara (letrozole tablets) for oral administration contain 2.5 mg of letrozole, a nonsteroidal aromatase inhibitor (inhibitor of estrogen synthesis). It is chemically described as 4,4'-(1H-1,2,4 -Triazol-1-ylmethylene) dibenzonitrile.

Letrozole is a white to yellowish crystalline powder, practically odorless, freely soluble in dichloromethane, slightly soluble in ethanol, and practically insoluble in water. It has a molecular weight of 285.31, empirical formula C17H11N5 and a melting range of 184o C-185o C.

Femara (letrozole tablets) is available as 2.5 mg tablets for oral administration.

Inactive Ingredients.
Colloidal silicon dioxide, ferric oxide, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, maize starch, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, talc, and titanium dioxide.

CLINICAL PHARMACOLOGY
Mechanism of Action
The growth of some cancers of the breast are stimulated or maintained by estrogens. Treatment of breast cancer thought to be hormonally responsive (i.e., estrogen and/or progesterone receptor positive or receptor unknown) has included a variety of efforts to decrease estrogen levels (ovariectomy, adrenalectomy, hypophysectomy) or inhibit estrogen effects (antiestrogens and progestational agents). These interventions lead to decreased tumor mass or delayed progression of tumor growth in some women.

In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.

Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumorbearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.

Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Treatment of women with letrozole significantly lowers serum estrone, estradiol and estrone sulfate and has not been shown to significantly affect adrenal corticosteroid synthesis, aldosterone synthesis, or synthesis of thyroid hormones.

Pharmacokinetics
Letrozole is rapidly and completely absorbed from the gastrointestinal tract and absorption is not affected by food. It is metabolized slowly to an inactive metabolite whose glucuronide conjugate is excreted renally, representing the major clearance pathway. About 90% of radiolabeled letrozole is recovered in urine. Letrozole’s terminal elimination half-life is about 2 days and steady-state plasma concentration after daily 2.5mg dosing is reached in 2-6 weeks. Plasma concentrations at steady-state are 1.5 to 2 times higher than predicted from the concentrations measured after a single dose, indicating a slight nonlinearity in the pharmacokinetics of letrozole upon daily administration of 2.5mg. These steady-state levels are maintained over extended periods, however, and continuous accumulation of letrozole does not occur. Letrozole is weakly protein bound and has a large volume of distribution (approximately 1.9 L/kg).

Metabolism and Excretion
Metabolism to a pharmacologically-inactive carbinol metabolite (4, 4'-methanol-bisbenzonitrile) and renal excretion of the glucuronide conjugate of this metabolite is the major pathway of letrozole clearance. Of the radiolabel recovered in urine, at least 75% was the glucuronide of the carbinol metabolite, about 9% was two unidentified metabolites, and 6% was unchanged letrozole.

In human microsomes with specific CYP isozyme activity, CYP 3A4 metabolized letrozole to the carbinol metabolite while CYP 2A6 formed both this metabolite and its ketone analog. In human liver microsomes, letrozole strongly inhibited CYP 2A6 and moderately inhibited CYP 2C19.

Special Populations
Pediatric, Geriatric and Race: In the study populations (adults ranging in age from 35 to >80 years), no change in pharmacokinetic parameters was observed with increasing age. Differences in letrozole pharmacokinetics between adult and pediatric populations have not been studied. Differences in letrozole pharmacokinetics due to race have not been studied.

Renal Insufficiency: In a study of volunteers with varying renal function (24-hour creatinine clearance: 9-116 mL/min), no effect of renal function on the pharmacokinetics of single doses of 2.5mg of Femara (letrozole tablets) was found. In addition, in a study of 347 patients with advanced breast cancer, about half of whom received 2.5mg Femara and half 0.5mg Femara, renal impairment (calculated creatinine clearance: 20-50 mL/min) did not affect steady-state plasma letrozole concentration.

Hepatic Insufficiency: In a study of subjects with varying degrees of non-metastatic hepatic dysfunction (e.g., cirrhosis, Child-Pugh classification A and B), the mean AUC values of the volunteers with moderate hepatic impairment were 37% higher than in normal subjects, but still within the range seen in subjects without impaired function. Patients with severe hepatic impairment (Child-Pugh classification C) have not been studied (see DOSAGE AND ADMINISTRATION, Hepatic Impairment).

Drug/Drug Interactions
A pharmacokinetic interaction study with cimetidine showed no clinically significant effect on letrozole pharmacokinetics. An interaction study with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics.

There is no clinical experience to date on the use of Femara in combination with other anti-cancer agents.

Pharmacodynamics
In postmenopausal patients with advanced breast cancer, daily doses of 0.1 mg to 5 mg Femara suppress plasma concentrations of estradiol, estrone, and estrone sulfate by 75%-95% from baseline with maximal suppression achieved within two-three days. Suppression is dose-related, with doses of 0.5 mg and higher giving many values of estrone and estrone sulfate that were below the limit of detection in the assays. Estrogen suppression was maintained throughout treatment in all patients treated at 0.5 mg or higher.

Letrozole is highly specific in inhibiting aromatase activity. There is no impairment of adrenal steroidogenesis. No clinically-relevant changes were found in the plasma concentrations of cortisol, aldosterone, 11-deoxycortisol, 17-hydroxy-progesterone, ACTH or in plasma renin activity among post-menopausal patients treated with a daily dose of Femara 0.1 mg to 5 mg. The ACTH stimulation test performed after 6 and 12 weeks of treatment with daily doses of 0.1, 0.25, 0.5, 1, 2.5, and 5 mg did not indicate any attenuation of aldosterone or cortisol production. Glucocorticoid or mineralocorticoid supplementation is, therefore, not necessary.

No changes were noted in plasma concentrations of androgens (androstenedione and testosterone) among healthy postmenopausal women after 0.1, 0.5, and 2.5 mg single doses of Femara or in plasma concentrations of androstenedione among postmenopausal patients treated with daily doses of 0. 1 mg to 5 mg. This indicates that the blockade of estrogen biosynthesis does not lead to accumulation of androgenic precursors. Plasma levels of LH and FSH were not affected by letrozole in patients, nor was thyroid function as evaluated by TSH levels, T3 uptake, and T4 levels.

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ARIMIDEX - Anastrozole

A very new drug developed for the treatment of advanced breast cancer in women. It is manufactured by Zenica Pharmaceuticals and was approved for use in the United States at the end of December 1995. Specifically, Arimidex is the first in a new class of third-generation selective oral aromatase inhibitors5°. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex, except this drug blocks the action and not production of estrogen. The effects of Arimidex can be quite dramatic to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.

For the steroid using male athlete, Arimidex shows great potential. Up to this point, drugs like Nolvadex and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Arimidex appears able to do the job much more efficiently, and with less hassle. Its use is only now catching on, but early reports have been excellent. A single tablet daily, the same dose use clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 2 tablet daily). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (finasteride, see Proscar), we have a great advance. With the one drug halting estrogen conversion and the other blocking 5-alpha reduction (testosterone, methyltestosterone and Halotestin only), related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.

There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex is shown not to display an antiestrogenic effect on cholesterol values, it is certainly the preferred from of estrogen maintenance for those concerned with cardiovascular health.

Arimidex has another principle drawback, namely the great price of this drug. Tablets can easily sell for $10 each, becoming quite costly with regular use. ! am currently looking at the product list of a reliable European anabolics dealer, who sells Arimidex® in packages of 28 tablets for $250. Clearly the price of an ancillary drug can be much greater than the steroids themselves, a situation destined not to be popular with recreational bodybuilders. Competitors on the other hand are likely to welcome this item. It can ward off the side effects of strong androgen therapy much better than Nolvadex and/or Proviron , making heavy cycles much more comfortable. As the number of countries manufacturing this drug increases, we may be able to look forward to a reduction in price. On a list from a Greek supplier (a country where drugs are government subsidized) for example, the price was nearly $100 better per box. Privately compounded versions of "liquid Arimidex have also been formulated "for research purposes" and are currently circulating the black market. They contain a high concentration of anastrozole (1 mg to 4mg/ml) in a liquid solution, which can be used orally, and represent very cost-effective alternatives for buying the brand name drug (typically selling for $5 per milligram or less).

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HCG - Human Chorionic Gonadotropin

Pregnyl by Organon. 5,000 to 20,000 IU (International Units) per 10 cc vials. This drug is not a steroid but it is widely used in athletics today. HCG is a natural protein hormone secreted by the human placenta and purified form the urine of pregnant women. This hormone is not a natural male hormone but mimics the natural hormone LH (Luetinising Hormone) almost identically. This LH stimulates the production of testosterone by the testis in males. Thus HCG sends the same message and results in increased testosterone production by the testis due to HCG’s effect on the leydig cells of the testis.

Normally this HCG is used to treat women with certain ovarian disorders and it is used to stimulate the testis of men who may be hypogonadal. Athletes use HCG to increase the body’s own natural production of testosterone which is often depressed by long term steroid use. Also when steroids are used in high dosages they can cause false signals to the hypothalamus that results in a depressed signal to the testicles. Over a period of weeks of this depressed signal the testicles ability to respond to any signal from the pituitary becomes very weak, which results in testicular atrophy. To avoid this athletes will use HCG to keep an artificial signal going to the testis and preventing testicular atrophy. When administered, HGC raises serum testosterone very quickly. A rise in testosterone firs appears in about two hours after injecting HCG. The second peak occurs about two to four days later.

HCG therapy has been found to be very effective in the prevention of testicular atrophy and to use the body’s own biochemical stimulating mechanisms to increase plasma testosterone level during training. Some steroid users find that they have some of their best strength and size gains while using HCG in conjunction with the steroids. This may wee be due to the facts that the body has high level of natural androgens as well as the artificial steroid hormones at that time.

The optimal dosage for an athlete using HCG has never been established, but it is thought that a single shot of 1000 to 2000 IU per week will get the desired results. Cycles on the HCG should be kept down to three weeks at a time with an off cycle of at least a month in between. For example, one might use the HCG for two to three weeks in the middle of a cycle, and for two or three weeks at the end of a cycle. It has been speculated that the prolonged use of HCG could repress the body’s own production of gonadotropins permanently. This is why the short cycles are the best way to go.

The side effects from HCG use include gynecomastia, water retention, and an increase in sex drive, mood alterations, headaches, and high blood pressure. HCG raises androgen levels in males by up to 400% but it also raises estrogen levels dramatically as well. This is why it can cause a real case of gynecomastia if dosages get too elevated for that person. Another side effect seen from HCG use is morning sickness (nausea and vomiting). There have been no cases of overdose complications with the use of HCG nor have there been any associated carcinomas, liver or renal impairment. HCG was at one point looked at to see if it could carry the AIDS virus, due to the fact that it is biologically active, but the latest word is that this could not be possible in any way.

So we see how HCG be used by athletes to avoid some of the problems associated with abruptly stopping a steroid cycle. This product is also not picked up on steroid tests, so some athletes use it to keep androgen levels high before a contest that has drug testing. HCG must be refergerated after it is mixed together, and it then has a life of about 10 weeks. It is taken intramuscularly only; this drug is often available by order of a physician if you show symptoms of hypogonadism. It is hard to find on the black market.

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Human Growth Hormone - FAQ


Rating: (1 being the lowest, 5 being the highest)
Strength-4
Weight Gain-4
Fat Loss-4
Side Effects-2
Keep Gains--4

Side Effects:
Hypoglycemia- due to lowered Insulin levels.
Aromeglia- (abnormal bone growth) GH does not cause it, but if you are predisposed to it, it will speed it up.
GH gut- if predisposed and taking large doses of GH
Carpel Tunnel Syndrome
Soreness in Joints

Benefits of GH:
New Muscle Cells
Mood Enhancement
Smoothing and improving the skin
Leanness, it is a potent fat burner
Joint and ligament strengthening

Where to Inject, How, and How to Make:
You can site inject anywhere you can reach the subcutaneous layer. Pinch the flesh and pull back, then insert the needle in the "pocket" underneath. Doesn't absorb quick enough if you inject into the adipose tissue. Do not inject intra-muscular, though it can be done, it is not recommended. GH is a site injection, where it is shot is where it will burn the most noticeable fat. Most people do it in the stomach since that is a typical sub q shot with most of the fat being in that area. GH should be kept in a fridge; freezing will destroy the GH. On your kit it probably says to use the kit in 18-24 hours, remember these are for AIDS patients, not bodybuilders or athletes. Mixing the GH can either be done with sterile water or bacteriostic water. The kit with water will be fine for 3 days in the fridge, even with the sterile water, but you should not take this chance, rather you should use bacteriostic water and play it safe. This will keep it fine for a couple of weeks. When mixing the GH, let the water slide down the side as to not pulverize the GH wafer. Do not spray it directly against the wafer with any force. Before reconstitution and even after GH is fragile!!! Also once the water is injected into the bottle gently swirl the vial to reconstitute, do not shake or swirl violently!!!!

Conversions:
1 ml = 1 cc -/+
100 units per 1 cc

6 mg = 18iu

1 ml = 18iu

.50 ml = 9iu

.25 ml = 4.5iu

Some people choose to only do it in cc’s but here is how you can do it in units on a slin dart

5.5 = 1iu, so 2iu = 11 on a slin dart

Dose:
4 to 6 iu ed is sufficient. Most people take it 5 days on 2 days off at their designated dosage. There is no reason or evidence why you cannot stay on for various lengths of time; there is no need to go 5 on 2 off other than cost. Considering that our natural production is only .5 to 1.5iu a day, this is still a huge bump for the body. Research has shown that the body's natural defense systems render mega doses of GH ineffective, anyway. GH does not cause gains in mass...it allows you to put on a great deal of lean mass in combination with proper steroid and Insulin use. The user before taking must know this. One or two kits are not enough, you need at least 3 to make you happy, GH takes a while to make its effects, but remember they are long lasting, what you see is what you keep. It takes 6 to 8 weeks to notice a dramatic change in body comp using GH on an ED or 5/2 split. Lighter doses for long periods of time are better than large doses for short cycles. Like any other drug, the more you take the more the benefits, but likewise also more risks. 4-6 iu is a standard dose but many people take more, the most repulsing side effects happen at or beyond 12 iu a day but like anything else it depends on your predisposition for it.

How to Stack:
GH is best taken in conjunction with Insulin, anabolic steroids, and t3. Insulin is extremely effective with GH, as anyone here who has tried it will testify. This is because GH injections cause a down regulation of Insulin sensitivity in the body.
GH alone causes little growth of lean mass, however, when combined with Insulin and steroids (and IGF-1 if you can find it), the results can be down right remarkable...esp. in the older bodybuilder. Start light with the humulin...5iu...and work up 1 iu a day till you get use to it. 7 to 10iu in the AM and 7 to 10 iu in the late afternoon, with split doses of GH is your best bet. When splitting GH/Insulin doses, I use mid-morning and late afternoon after lifting.... both flat times in our natural GH production. The Insulin overcomes the Insulin-resistance caused by exogenous GH supplementation. If you are scared to take Insulin thought, then Gh with Test and Glucophage is good. GH is good for cutting if used alone. Glucophage allows for improved glucose and amino acid absorption by the muscle tissue and does it safely. This is what you want. The half-life of GH is only 2 hours so spread it out. Avoid bedtime injections since we produce the bulk of our own GH in the first two hours of sleep. Since exogenous GH suppresses this, you should not take it before bed. For best results, use a 17aa oral during the cycle to stimulate the release of natural Insulin growth factors. I would run the test throughout. GH/Insulin/test is the proven synergistic combination.
It is also wise to preload with testosterone before starting GH if you are going to do it. You should preload with the amount of time it takes for that testosterone to kick in, since most of us take longer acting esters for testosterone you should usually start taking the test 2 weeks before GH use. Likewise, you can accommodate it to fit your needs; the key is for the test to be kicking in the same time you are starting to run your GH. You can cycle you steroids however you want to depending on your goals, if you are going for a more massive look than you would run Insulin for most of the cycle and use high androgens, but if you are looking for additional leanness at the end of a cycle you should stop the androgens and run a higher dose of GH or run less androgens. T3 is also another substance that should be used during GH cycling since GH lowers thyroid hormones. T3 should be used for shorter periods though, because it can permanently alter the endocrine system. The magic of GH for men is the ability to gain mass without fat or bloating when stacked properly with Insulin, and steroids. GH also makes for amazing improvements in skin...smoothes wrinkles, burns stubborn spots of adipose tissue, gives that paper-thin contest look...and also gives one a real mood lift, a feeling of well being.

Major Difference Between GH and Steroids:
Steroids can increase the size of your muscle cells, but cannot I repeat CAN NOT increase the number of muscle cells in your body, which to start with is governed by your genetics. However Growth hormone CAN increase the number of muscle cells in your body, which goes beyond genetics.

Half-Life of GH:
Exogenous (injected) GH has a "half-life" of approximately 2 hours . . . a 4-hour period of activity during which there is a suppression of naturally produced GH.

GH Naturally Produced:
We release the most of our naturally produced GH during the first two hours of deep sleep...you may take a little time to adjust.... your body thinks you should be in bed when that big influx hits. It is good to take a nap, that’s when you grow anyway. It always helps to take naps after workouts and injections everyday.

GH Causing Acromeglia:
Acromeglia is a disease...you either have it or you don't. Supplementing GH will not cause it. Persons suffering from acromeglia, like Andre the Giant, lack the natural defense mechanisms of the body to regulate the production and effects of GH secretion in he pituitary. It is well established in the medical literature that exogenous GH will not cause the disease.... of course it would worsen the condition in those who had it.

GH Gut: Myth or Reality?:
Some researchers claim that any gains in weight experienced by subjects using GH alone was due to growth of internal organs and connective tissue, which could cause some problems. Most studies do not agree with this theory and consider "GH gut" to be a myth. Some people are allergic to synthetic test, this is something you have to find out for yourself. Some people also feel intestinal discomfort from time to time, if so take it down to one item at a time to see what is causing you discomfort; creatine , glutamine, protein products, orals, and dirty gear have all been known to cause this, so find the problem early.

GH and IGF-1:
Perhaps the most relevant effect of IGF-1 is the ability of IGF-1 to increase protein synthesis by increasing cellular mRNA formation (mRNA makes protein) as well as increasing uptake of amino acids. This effect on protein synthesis can lead to increased lean mass. The research indicates that this effect is dependent on GH presence as well. So IGF-1 alone does not promote such effects. Nor does GH. It appears the combination of the two most consistently lead to increased protein synthesis.

GH and IGF-1 are negative regulators of GH release so an increase in either (from a GH injection) reduces the secretion of GH. IGF-1 is very difficult to obtain in a useable condition.... it must be handled very gently and have bee kept at a rather precise temperature at all times. One can stimulate IGF production through the use of an oral steroid during cycle. Dbol, for example, causes a rather extensive release of IGF during the first pass through the liver.

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IGF-1 Long R3

IGF stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body; I will only mention the points that would be important for physical enhancement. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

There is a lot of talk about the similarity between IGF and growth hormone. The most often asked question is simply which is more effective. GH doesn't directly cause your muscles to grow, it works very indirectly by increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and increasing the amount of anabolic steroids a person can use effectively. GH also indirectly causes muscle growth by stimulating the release of IGF when it (the GH) is destroyed in the human body. So one way you could look at it as GH being a precursor to IGF. So to put it simple IGF is more effective at directly causing muscle growth and density increases. IGF is also much more cost effective.

IGF can also be effectively used by itself and gains will still be easily noticeable. With growth hormone you need to use high amounts of anabolics and often insulin to see any gains at all, this is not the case with IGF. IGF can be used by itself and is often used by bodybuilders who bridge between cycles, during this bridge is a good time to use IGF since it has no effect on natural testosterone production so it will therefore allow you to return to normal in terms of hormone levels. A stack of IGF, PGF2a, HCG, and clomid would be a good bridge stack and would allow your body to return to normal and still allow you to retain and make new gains.

IGF is a research drug, it hasn't been approved by the FDA for use as a pharmaceutical and it is currently being researched for nerve tissue repair, possible burn victims, and also as a possible aid in muscle wasting for AIDS patients. There are many different analogs of IGF available, instead of mentioning them all, I will simply mention the two most common and the most effective. Regular recombinant IGF is one of the two, it is also the more expensive and the least effective. Regular IGF only has a half-life of about 10-20 minutes in the human body and is quickly destroyed, it can be combined with certain binding proteins to extend the half-life, but it is not a very simple procedure and there is a more effective and less expensive version available. The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."

"Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's."

It is also not as expensive since a media grade version is available which is sufficient for bodybuilding use. There is also a receptor grade available but it is VERY expensive and the only noticeable difference between the two would only be able to be noticed in a laboratory setting. The price on the black market for Long R3 IGF-1 can be seen anywhere from $300-$500 per milligram depending on the source, be wary of black market dealers of any IGF since it is a VERY difficult item to obtain. As mentioned IGF is a research product and is only available from a few laboratories in the world and is only available to research companies and biotechnology institutions. For the rest of this article when I say IGF I am now referring to Long R3 IGF-1 for simplicity sake.

Any form of IGF is ONLY supplied in a lyphosized form, which means a dry powder state. NEVER PUCHASE PRE-DILUTED LIQUID IGF!!!! There is no such product made anywhere in the world and even if there were real IGF ever present in the vial it would all be dead by the time you receive it. IGF is a very delicate peptide and must be diluted by yourself, where you have access to a refrigerator and freezer. There has also been a lot of talk by certain sources claiming to have IGF made by the Eli Lilly company, to clear things up Lilly is a pharmaceutical company and as stated IGF is a research drug and has not yet been approved, Lilly does not and never has manufactured research drugs for retail sale.

The dilutents you will need for the IGF are a weak concentration of hydrochloric acid and a sterile buffer(sterile water or bacteriostatic water) the procedure for diluting the IGF is not very difficult, the dilutents can be obtained from most local chemical suppliers and a good source of IGF would also be able to supply the necessary dilutents.

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage. The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results, and in fact several top bodybuilders use the 20mcg/day dosage and are pleased with the results. IGF is most effective when administered subcutaneously and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training.

Another frequently asked question of IGF refers to the real world results, in terms of pure weight gain don't expect to gain 5 lbs. a week like you may off of anadrol or a similar steroid. The only weight you will gain from IGF use is pure lean muscle tissue, with steroids most of the weight gained is water weight. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks and these effects can be increased with the use of testosterone, anabolic steroids, and insulin use. Increased vascularity is also very common, people report seeing veins appear where they never have before. And yet another effect reported is the ability to stay lean while bulking with heavy dosages of steroids and TONS of food while on an IGF cycle, this is perhaps the most pleasing effect. Increased pumps are also noticeable almost immediately, the pumps can almost become painful, pumps are even noticeable when doing cardio.

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities. If you can find a trustworthy source and you use it correctly it can be a VERY useful tool in your bodybuilding drug arsenal.

Long™R3IGF-I is an analog of human IGF-I.
· It is a superior alternative to insulin in serum-free media.
· It increases protein production by cells in culture medium.
· It increases cell viability by inhibiting apoptosis.
· It has a longer half-life in cell culture than insulin.
· It is readily available.
· There is secure and ample manufacturing capacity at GroPep Limited.
· No animal- or human- derived material is used in the manufacture or storage of Long™R3IGF-I.
· Long™R3IGF-I is already being used in the manufacture of three (3) biopharmaceuticals approved by FDA and EMEA.

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IGF-1 Long R3 Continued...

Frequently Asked Questions

What cell types will respond to Long™R3IGF-I?
All cells that have a Type I IGF receptor will potentially respond. Most commercially used cells including CHO, fibroblasts and hybridomas have a type I IGF receptor. All cells which respond to pharmacological concentrations of insulin (>1 mg/liter) will respond to Long™R3IGF-I (10-50 mg/liter).

Is storage of the stock solution at 4°C acceptable?
Yes

How long is the stock solution stable for under these storage conditions?
Liquid stability data shows that Long™R3IGF-I is stable for 3 years (-20°C to 37°C). Therefore, the stock solution should be stable at 4°C for 3 years.

What type of preparation is available?
Liquid formulation, preferable for GMP production.
Freeze dried preparation.

Is Long™R3IGF-I stable?
Re-test date for freeze-dried peptide is 3 years. Liquid formulation stability studies have recently been completed. It is stable for 3 years (-20°C to +37°C). We have data indicating stability in media at 4°C for 1 year.

Here is an article written by a self-experimenter.

December 15, 2000

Answer: What a perfect question! You actually have talked to just the right person. I have a business associate that worked for the company that produces this in Australia. Several years ago, I ordered 10mg of Long R3 IGF-1 and used it for several months. What I found out was truly amazing.

Before I tell you about my results, let me tell you that if you are going to use IGF-1 then make sure it is the Long R3 version! Let me explain. Regular IGF-1 like what is produced in your body is transported around connected to binding proteins. There are quite a few of these and their main purpose is to grab ahold of the IGF-1 peptide and keep it from being quickly degraded. Without these binding proteins, all of the IGF-1 would be metabolized in the body within a few minutes. The problem (at least it seems like a problem but might actually be a good thing) is that these binding proteins basically prevent the IGF-1 from performing its function. As long as IGF-1 is attached to the binding protein it cannot do the cool stuff that it wants to do. Regular IGF-1 must be released from its binding protein in order to accomplish its mission. Part of the problem is that much of the IGF-1 is degraded before it is released (seems like much is wasted doesn’t it?)

With Long R3 IGF-1 this problem doesn’t exist. Understand that the Long R3 version does not bind to the various binding proteins. It is free to move throughout your body and immediately start doing all the cool stuff that it wants to do. Again, understand that the Long R3 version is several orders of magnitude stronger than regular IGF-1.

If you would happen to use regular IGF-1, you would need several milligrams per day in order to get the desired effect. With the Long R3 version, you need only microgram quantities. Long R3 is also inherently MUCH cheaper to produce. What I am saying is that for the average person, regular IGF-1 is not practical-it is too expensive and you need to use too much. With Long R3 IGF-1, the price to results ratio is pretty good!

Something else I want to explain is how I went about preparing it for injection into my body. Unfortunately, this is not easy and the average person will have a hard time doing it. At the time, I worked in a sophisticated lab which had all of the necessary equipment. I ordered 10mg of Long R3 IGF-1 and it came in a single flip-top vial. 10mg might not seem like much but believe me, when it comes to Long R3 IGF-1, it is a ton! Some people might say to just add saline to the vial, keep it in the fridge and inject it when necessary. However, this will not work well because the IGF-1 is not highly stable and will degrade in an aqueous environment. 10mg was enough for many months and I needed a way that would allow the IGF-1 to remain potent during this entire time. I did my research and developed my method. I ordered what is known as microvials and sterilized them. I then diluted the IGF-1 with sterile water and added just a tad of acid to increase stability. Although it took quite a while, I then used a micropipette and alliquotted an amount of solution that contained 50mcg into one of my microvials. I closed the microvial and then froze it in a deep freezer. When I was ready to inject, I took out one or more of my microvials, thawed it out, combined it with saline and injected it.

When I first started taking Long R3 IGF-1, I used 50mcg every other day. Amazingly, within days, I started noticing some effects in my body. I felt super hungry all of the time and just felt “anabolic”. I can’t describe this feeling except to say that it was very similar to being on anabolic steroids (I wasn’t on at the time). Within one month, I gained almost 17 pounds of fairly lean mass! After the first month, something happened though and I noticed that it didn’t seem to be working that well. I upped the dosage several times over the next month to keep up the desired effects. On the third month, I was using several hundred micrograms per day but wasn’t noticing any further gains. All in all, I gained about 20 pounds of pretty solid mass!

Please notice that almost all of my gains were within the first month of taking the Long R3 IGF-1. After this first month, my gains slowed down considerably and eventually stopped altogether even though I was taking high dosages. Why did this happen?

From all of my research, I suppose one of two things might have happened to prevent me from making further gains. What I truly suspect is that the Long R3 IGF-1 downregulated the amount of binding proteins being produced by my body (research confirms this). When I first started to inject the IGF-1, I was supplementing my own body’s IGF-1. I not only had my own IGF-1 working throughout the day but I had the potent surges of Long R3 IGF-1 that I would inject. Over time though, the binding proteins were downregulated. Of course my body continued to produce some (albeit less) IGF-1, however, because there were very little or no binding proteins it was quickly degraded. From what I can tell, I was in a state where 95% of the day my body did not have the benefits of IGF-1. Basically, it got what it got when I injected the Long R3 version.

The other possibility is that I built up antibodies to the Long R3 IGF-1 which basically sought out and destroyed what I injected. Although possible, I don’t believe this actually happened because it is not supported by research. I have seen no evidence which suggests that Long R3 IGF-1 causes antibody production.

To fix the above problem, one would have to cycle the Long R3 IGF-1. The best thing would probably be to take it every other month. This would allow your own body’s IGF-1 and binding proteins to return to normal.

Overall, I had a good experience with Long R3 IGF-1. The results were different than with steroids. I have noticed that steroids cause preferential growth of certain muscles, especially those that are stressed (as in lifting). The IGF-1 though seemed to cause my entire body to get a little thicker. I guess IGF-1 is less compensatory in nature and exerts a more whole-body anabolicity.

Would I recommend IGF-1? To the right person who is very careful and knows what he’s doing and has a good background in the sciences and has access to a good lab, YES! However, you can tell that I have listed many prerequisites to using it. For the average Joe, I believe is is just too complicated to be safe.